2-BROMO-4-METHOXYBENZOTHIAZOLE

Base Information

• Chemical Name: 2-BROMO-4-METHOXYBENZOTHIAZOLE
• CAS No.: 3622-39-7
• Molecular Formula: C8H6 Br N O S
• Molecular Weight: 244.11
• Hs Code.: 29342000
• Mol file: 3622-39-7.mol

Synonyms:2-Bromo-4-methoxybenzothiazole

Chemical Property of 2-BROMO-4-METHOXYBENZOTHIAZOLE

Chemical Property:

• Melting Point: 71 °C
• Boiling Point: 335.4±34.0 °C(Predicted)
• PKA: -0.08±0.10(Predicted)
• PSA: 50.36000
• Density: 1.666±0.06 g/cm3(Predicted)
• LogP: 3.06740

Purity/Quality:

NLT 98% ^*data from raw suppliers

2-Bromo-4-methoxybenzo[d]thiazole 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BROMO-4-METHOXYBENZOTHIAZOLE

There total 2 articles about 2-BROMO-4-METHOXYBENZOTHIAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4-methoxy-1,3-benzothiazol-2-amine (5464-79-9) → 2-bromo-4-methoxybenzo[d]thiazole (3622-39-7)

Guidance literature:

With tert.-butylnitrite; tetrabutylammomium bromide; toluene-4-sulfonic acid; In water; acetonitrile; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1039/c6cc05112j

Reference yield:

→ 2-bromo-4-methoxybenzo[d]thiazole (3622-39-7)

Guidance literature:

With hydrogen bromide; copper;

DOI:10.1002/hlca.19420250306

Reference yield: 95.0%

2-bromo-4-methoxybenzo[d]thiazole (3622-39-7) + 4-fluoroboronic acid (1765-93-1) → 2-(4-fluorophenyl)-4-methoxybenzo[d]thiazole (940287-39-8)

Guidance literature:

With bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); caesium carbonate; In water; toluene; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1039/c6cc05112j

upstream raw materials:

4-methoxy-1,3-benzothiazol-2-amine

Downstream raw materials:

2-(4-fluorophenyl)-4-methoxybenzo[d]thiazole

Refernces

• 1、 -. "CYCLOPROPYL UREA FORMYL PEPTIDE 2 RECEPTOR AND FORMYL PEPTIDE 1 RECEPTOR AGONISTS". Page/Page column 42; 43. . Retrieved 2019/01/06.