N-(4-Chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide

Base Information

• Chemical Name: N-(4-Chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide
• CAS No.: 269390-69-4
• Molecular Formula: C₁₉H₁₆ClN₃O
• Molecular Weight: 337.809
• DSSTox Substance ID: DTXSID60430900
• Nikkaji Number: J2.010.656E
• Wikidata: Q27089133
• Pharos Ligand ID: Q9S8WULZ88DR
• Metabolomics Workbench ID: 150469
• ChEMBL ID: CHEMBL101683
• Mol file: 269390-69-4.mol

Synonyms:269390-69-4;N-(4-Chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide;VEGFR Tyrosine Kinase Inhibitor II;VEGFR-IN-1;VEGF Receptor Tyrosine Kinase Inhibitor II;N-(4-chlorophenyl)-2-(pyridin-4-ylmethylamino)benzamide;AG-E-85378;CHEMBL101683;N-(4-Chlorophenyl)-2-((pyridin-4-ylmethyl)amino)benzamide;3hng;D07SRX;GTPL6056;SCHEMBL3005186;DTXSID60430900;GGPZCOONYBPZEW-UHFFFAOYSA-N;HMS3229O07;BDBM50132151;CCG-206804;DB07288;NCGC00387770-01;MS-25133;HY-101219;CS-0021004;J-016613;Q27089133;N-(4-Chlorophenyl)-2-(4-pyridinylmethylamino)benzamide;N-(4-chlorophenyl)-2-[(4-pyridylmethyl)amino]benzamide;N-(4-Chlorophenyl)-2-[(4-pyridinylmethyl)amino]benzamide;VEGFR Tyrosine Kinase Inhibitor II - CAS 269390-69-4;N-(4-Chloro-phenyl)-2-[(pyridin-4-ylmethyl)-amino]-benzamide;8ST;N-(4-Chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide, VEGF Receptor Tyrosine Kinase Inhibitor II

Chemical Property of N-(4-Chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide

Chemical Property:

• Boiling Point: 463.6±40.0 °C(Predicted)
• PKA: 12.62±0.70(Predicted)
• PSA: 54.02000
• Density: 1.331±0.06 g/cm3(Predicted)
• LogP: 4.74540
• XLogP3: 4.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 337.0981898
• Heavy Atom Count: 24
• Complexity: 392

Purity/Quality:

98%+ ^*data from raw suppliers

VEGFRTyrosineKinaseInhibitorII ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C(=O)NC2=CC=C(C=C2)Cl)NCC3=CC=NC=C3
• Uses: VEGFR Tyrosine Kinase Inhibitor II is an agent that potently inhibits kinase activities of KDR, Flt-1 and c-Kit.

Technology Process of N-(4-Chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide

There total 8 articles about N-(4-Chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

pyridine-4-carbaldehyde (872-85-5) + 2-amino-N-(4-chlorophenyl)benzamide (4943-86-6) → VEGF Receptor Tyrosine Kinase Inhibitor II (269390-69-4)

Guidance literature:

With sodium cyanoborohydride;

DOI:10.1016/j.bmcl.2007.07.077

Reference yield:

N-(4-Chloro-phenyl)-2-{[1-pyridin-4-yl-meth-(E)-ylidene]-amino}-benzamide → VEGF Receptor Tyrosine Kinase Inhibitor II (269390-69-4)

Guidance literature:

With sodium cyanoborohydride; In methanol; at 20 ℃; for 2h;

DOI:10.1016/S0960-894X(03)00626-7

Reference yield:

2-(tert-butyloxycarbonylamino)benzoic acid (68790-38-5) → VEGF Receptor Tyrosine Kinase Inhibitor II (269390-69-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 35 percent / HBTU; NMM / dimethylformamide / 16 h / 20 °C

2: 97.9 percent / aq. HCl / dioxane; methanol / 3.5 h / 20 °C

3: AcOH / methanol / 2 h / 20 °C

4: 0.200 g / NaCNBH₃ / methanol / 2 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; sodium cyanoborohydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(03)00626-7

upstream raw materials:

pyridine-4-carbaldehyde

2-amino-N-(4-chlorophenyl)benzamide

2-(tert-butyloxycarbonylamino)benzoic acid

anthranilic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 269390-69-4 N-(4-CHLOROPHENYL)-2-[(PYRIDIN-4-YLMETHYL)AMINO]BENZAMIDE

Send

Send

Metric Ton KG G Pound L ML

Send

Send