Technology Process of 6-(3-(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dienyl)propylthio)hexyl nitrate
There total 7 articles about 6-(3-(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dienyl)propylthio)hexyl nitrate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
ammonium cerium (IV) nitrate;
In
water; acetonitrile;
at 20 ℃;
for 3h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 16 h / 0 - 20 °C
1.2: 0.5 h / 0 °C
2.1: triethylamine; dmap / dichloromethane / 5 h / 0 °C
3.1: sodium iodide / N,N-dimethyl-formamide / 3 h / 20 °C
4.1: sodium methylate / methanol / 0.25 h / 20 °C
4.2: Amberlite? IR-120H
5.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 0 - 20 °C
6.1: tetraethylammonium nitrate; 2,6-di-tert-butyl-4-methylpyridine; trifluoromethylsulfonic anhydride / dichloromethane / 3 h / -78 °C / Inert atmosphere
7.1: ammonium cerium (IV) nitrate / acetonitrile; water / 3 h / 20 °C
With
dmap; 2,6-di-tert-butyl-4-methylpyridine; ammonium cerium (IV) nitrate; trifluoromethylsulfonic anhydride; sodium methylate; tetraethylammonium nitrate; caesium carbonate; triethylamine; 9-bora-bicyclo[3.3.1]nonane; sodium iodide;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium iodide / N,N-dimethyl-formamide / 3 h / 20 °C
2.1: sodium methylate / methanol / 0.25 h / 20 °C
2.2: Amberlite? IR-120H
3.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 0 - 20 °C
4.1: tetraethylammonium nitrate; 2,6-di-tert-butyl-4-methylpyridine; trifluoromethylsulfonic anhydride / dichloromethane / 3 h / -78 °C / Inert atmosphere
5.1: ammonium cerium (IV) nitrate / acetonitrile; water / 3 h / 20 °C
With
2,6-di-tert-butyl-4-methylpyridine; ammonium cerium (IV) nitrate; trifluoromethylsulfonic anhydride; sodium methylate; tetraethylammonium nitrate; caesium carbonate; sodium iodide;
In
methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
