(R)-4-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-methylheptanoic acid

Base Information

Chemical Name:(R)-4-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-methylheptanoic acid
CAS No.:269078-75-3
Molecular Formula:C23H27 N O4
Molecular Weight:381.472
Hs Code.:29225090
DSSTox Substance ID:DTXSID401151806
Mol file:269078-75-3.mol

Synonyms:269078-75-3;(R)-4-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-methylheptanoic acid;(R)-Fmoc-4-amino-6-methyl-heptanoic acid;(4R)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-6-methylheptanoic acid;(4R)-4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-6-methylheptanoic acid;Fmoc-gamma-L-leucine;DTXSID401151806;MFCD02094561;AKOS022172980;AC-25322;AS-73015;D86523;(4R)-4-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-6-methylheptanoic acid;(R)-4-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-methylheptanoicacid

Suppliers and Price of (R)-4-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-methylheptanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R)-Fmoc-4-amino-6-methyl-heptanoicAcid
250mg
$ 315.00

Crysdot
(R)-4-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-methylheptanoicacid 97%
5g
$ 795.00

Chemenu
(R)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-6-methylheptanoicacid 97%
5g
$ 751.00

American Custom Chemicals Corporation
(R)-FMOC-4-AMINO-6-METHYL-HEPTANOIC ACID 95.00%
100MG
$ 179.55

AK Scientific
(R)-Fmoc-4-amino-6-methyl-heptanoicacid
250mg
$ 279.00

Total 10 raw suppliers

Chemical Property of (R)-4-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-methylheptanoic acid

Chemical Property:

Boiling Point:588.8±33.0 °C(Predicted)
PKA:4.62±0.10(Predicted)
PSA：75.63000
Density:1.171±0.06 g/cm3(Predicted)
LogP:5.19550
Storage Temp.:Store at -15°C
XLogP3:4.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:9
Exact Mass:381.19400834
Heavy Atom Count:28
Complexity:513

Purity/Quality:

98%Min ^*data from raw suppliers

(R)-Fmoc-4-amino-6-methyl-heptanoicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)CC(CCC(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13
Isomeric SMILES:CC(C)C[C@@H](CCC(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13

Technology Process of (R)-4-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-methylheptanoic acid

There total 3 articles about (R)-4-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-methylheptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 22818-46-8
(4R)-4-amino-6-methylheptanoic acid

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 269078-75-3
(R)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-6-methylheptanoic acid

Guidance literature:: With sodium carbonate; In tetrahydrofuran; water; at 0 - 20 ℃; pH=Ca. 10;
DOI:10.1002/cmdc.201700370

Reference yield:

: 146453-32-9
(R)-4-([(tert-butoxy)carbonyl]amino)-6-methylheptanoic acid

: 269078-75-3
(R)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-6-methylheptanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 0.5 h / 0 °C

2: sodium carbonate / tetrahydrofuran; water / 0 - 20 °C / pH Ca_. 10

With sodium carbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water;
DOI:10.1002/cmdc.201700370

Reference yield:

: C₁₃H₂₃NO₄

: 269078-75-3
(R)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-6-methylheptanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: palladium on carbon; hydrogen / ethanol / 2 h / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 0.5 h / 0 °C

3: sodium carbonate / tetrahydrofuran; water / 0 - 20 °C / pH Ca_. 10

With palladium on carbon; hydrogen; sodium carbonate; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1002/cmdc.201700370