N-bis(trimethylsilyl)methyl-N-[2-(4-methoxyphenyl)ethyl]-α-diazoacetamide

Base Information

Chemical Name:N-bis(trimethylsilyl)methyl-N-[2-(4-methoxyphenyl)ethyl]-α-diazoacetamide
CAS No.:882408-52-8
Molecular Formula:C₁₈H₃₁N₃O₂Si₂
Molecular Weight:377.634
Hs Code.:

Synonyms:N-bis(trimethylsilyl)methyl-N-[2-(4-methoxyphenyl)ethyl]-α-diazoacetamide

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Chemical Property of N-bis(trimethylsilyl)methyl-N-[2-(4-methoxyphenyl)ethyl]-α-diazoacetamide

Chemical Property:

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Technology Process of N-bis(trimethylsilyl)methyl-N-[2-(4-methoxyphenyl)ethyl]-α-diazoacetamide

There total 5 articles about N-bis(trimethylsilyl)methyl-N-[2-(4-methoxyphenyl)ethyl]-α-diazoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 882408-57-3
N-(bis-trimethylsilanyl-methyl)-2-diazo-N-[2-(4-methoxy-phenyl)-ethyl]-3-oxo-butyramide

: 882408-52-8
N-bis(trimethylsilyl)methyl-N-[2-(4-methoxyphenyl)ethyl]-α-diazoacetamide

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 3h;
DOI:10.1016/j.tetasy.2005.12.020

Reference yield:

: 882408-55-1
N-(4-methoxyphenethyl)bis(trimethylsilyl)methylamine

: 882408-52-8
N-bis(trimethylsilyl)methyl-N-[2-(4-methoxyphenyl)ethyl]-α-diazoacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: DMAP / tetrahydrofuran

2: 81 percent / methanesulfonyl azide; DBU / acetonitrile

3: 74 percent / LiOH*H₂O / tetrahydrofuran; H₂O / 3 h / 20 °C

With dmap; lithium hydroxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; Methanesulfonyl azide; In tetrahydrofuran; water; acetonitrile;
DOI:10.1016/j.tetasy.2005.12.020

Reference yield:

: 882408-56-2
N-(bis-trimethylsilanyl-methyl)-N-[2-(4-methoxy-phenyl)-ethyl]-3-oxo-butyramide

: 882408-52-8
N-bis(trimethylsilyl)methyl-N-[2-(4-methoxyphenyl)ethyl]-α-diazoacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / methanesulfonyl azide; DBU / acetonitrile

2: 74 percent / LiOH*H₂O / tetrahydrofuran; H₂O / 3 h / 20 °C

With lithium hydroxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; Methanesulfonyl azide; In tetrahydrofuran; water; acetonitrile;
DOI:10.1016/j.tetasy.2005.12.020