{(S)-1-[(S)-1-[(1S,2S)-1-Cyclohexylmethyl-2-hydroxy-4-(3-methyl-butylamino)-butylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

Base Information

Chemical Name:{(S)-1-[(S)-1-[(1S,2S)-1-Cyclohexylmethyl-2-hydroxy-4-(3-methyl-butylamino)-butylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester
CAS No.:108868-79-7
Molecular Formula:C₃₆H₅₈N₆O₅
Molecular Weight:654.894
Hs Code.:

{(S)-1-[(S)-1-[(1S,2S)-1-Cyclohexylmethyl-2-hydroxy-4-(3-methyl-butylamino)-butylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

Synonyms:{(S)-1-[(S)-1-[(1S,2S)-1-Cyclohexylmethyl-2-hydroxy-4-(3-methyl-butylamino)-butylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

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Chemical Property of {(S)-1-[(S)-1-[(1S,2S)-1-Cyclohexylmethyl-2-hydroxy-4-(3-methyl-butylamino)-butylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

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Technology Process of {(S)-1-[(S)-1-[(1S,2S)-1-Cyclohexylmethyl-2-hydroxy-4-(3-methyl-butylamino)-butylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

There total 10 articles about {(S)-1-[(S)-1-[(1S,2S)-1-Cyclohexylmethyl-2-hydroxy-4-(3-methyl-butylamino)-butylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108868-84-4
Boc-Phe-His amide of (3S,4S)-1-<(3-methylbutyl)(benzyloxycarbonyl)amino>-3-hydroxy-4-amino-5-cyclohexylpentane

: 108868-79-7
{(S)-1-[(S)-1-[(1S,2S)-1-Cyclohexylmethyl-2-hydroxy-4-(3-methyl-butylamino)-butylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In acetic acid; for 12h; under 760 Torr;
DOI:10.1021/jm00390a018

Reference yield:

: 98105-42-1
(S)-2-(t-butoxycarbonylamino)-3-cyclohexyl-1-propanal

: 108868-79-7
{(S)-1-[(S)-1-[(1S,2S)-1-Cyclohexylmethyl-2-hydroxy-4-(3-methyl-butylamino)-butylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) lithium diisopropylamide / 1.) THF, -78 deg C, 10 min, 2.) THF, -78 deg C, 15 min

2: 95 percent / H₂, NH₃ / Raney Ni / methanol / 2280 Torr

3: 5A molecular sieves / tetrahydrofuran / 24 h

4: NaCNBH₃ / tetrahydrofuran / 0.5 h / 0 °C

5: 72 percent / Et₃N / CH₂Cl₂ / 75 h / 0 - 20 °C

6: 4 M aq. HCl / dioxane

7: N-methylmorpholine, 1-hydroxybenzotriazole monohydrate, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / 14 h / -23 - 20 °C

8: H₂ / 10percent Pd/C / acetic acid / 12 h / 760 Torr

With 4-methyl-morpholine; hydrogenchloride; 5A molecular sieve; ammonia; hydrogen; sodium cyanoborohydride; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium diisopropyl amide; palladium on activated charcoal; nickel; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00390a018

Reference yield:

: 107202-61-9
(2R,3S)-3-(t-butoxycarbonylamino)-4-cyclohexyl-1,2-epoxybutane

: 108868-79-7
{(S)-1-[(S)-1-[(1S,2S)-1-Cyclohexylmethyl-2-hydroxy-4-(3-methyl-butylamino)-butylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 65 percent / methanol; H₂O / 18 h / Ambient temperature

2: 95 percent / H₂, NH₃ / Raney Ni / methanol / 2280 Torr

3: 5A molecular sieves / tetrahydrofuran / 24 h

4: NaCNBH₃ / tetrahydrofuran / 0.5 h / 0 °C

5: 72 percent / Et₃N / CH₂Cl₂ / 75 h / 0 - 20 °C

6: 4 M aq. HCl / dioxane

7: N-methylmorpholine, 1-hydroxybenzotriazole monohydrate, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / 14 h / -23 - 20 °C

8: H₂ / 10percent Pd/C / acetic acid / 12 h / 760 Torr

With 4-methyl-morpholine; hydrogenchloride; 5A molecular sieve; ammonia; hydrogen; sodium cyanoborohydride; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; nickel; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00390a018