2-(1-{3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoyl}-4-piperidinyl)acetic acid

Base Information

Chemical Name:2-(1-{3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoyl}-4-piperidinyl)acetic acid
CAS No.:937054-45-0
Molecular Formula:C₃₀H₃₂ClFN₂O₆
Molecular Weight:571.045
Hs Code.:

Synonyms:2-(1-{3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoyl}-4-piperidinyl)acetic acid

Suppliers and Price of 2-(1-{3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoyl}-4-piperidinyl)acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(1-{3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoyl}-4-piperidinyl)acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(1-{3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoyl}-4-piperidinyl)acetic acid

There total 11 articles about 2-(1-{3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoyl}-4-piperidinyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 937054-44-9
Ethyl 2-(1-{3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoyl}-4-piperidinyl)acetate

: 937054-45-0
2-(1-{3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoyl}-4-piperidinyl)acetic acid

Guidance literature:: With potassium carbonate;

Reference yield:

: 937057-61-9
(5-chloro-3-fluoro-2-pyrrol-1-ylphenyl)-(2,3-dimethoxyphenyl)methanone

: 937054-45-0
2-(1-{3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoyl}-4-piperidinyl)acetic acid

Guidance literature:: Multi-step reaction with 11 steps

1.1: trichlorophosphate / 0.25 h / 0 - 20 °C

1.2: 2.08 h / 0 - 50 °C

1.3: 0.5 h / 50 °C

2.1: toluene / 1 h / Heating / reflux

3.1: sodium tetrahydroborate / methanol / 1.5 h / 0 - 20 °C

3.2: 0 °C

4.1: trifluoroacetic acid / dichloromethane / 20 h / 0 - 20 °C

5.1: Resolution of racemate

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

6.2: 0 °C

7.1: triethylamine / dichloromethane / 1 h / 0 °C

8.1: dimethyl sulfoxide / 13 h / 50 °C

9.1: sodium hydroxide; water; isopropyl alcohol / 24 h / Heating / reflux

9.2: 0 °C

10.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C

11.1: potassium carbonate

With sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; isopropyl alcohol; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; toluene;

Reference yield:

: 937057-59-5
1-(2-Bromo-4-chloro-6-fluorophenyl)-1H-pyrrole

: 937054-45-0
2-(1-{3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoyl}-4-piperidinyl)acetic acid

Guidance literature:: Multi-step reaction with 13 steps

1.1: n-butyllithium / diethyl ether; hexane / 0.25 h / -78 - 0 °C

1.2: 1 h / -78 - 0 °C

2.1: manganese(IV) oxide / dichloromethane / 14 h / 20 °C / Heating / reflux

3.1: trichlorophosphate / 0.25 h / 0 - 20 °C

3.2: 2.08 h / 0 - 50 °C

3.3: 0.5 h / 50 °C

4.1: toluene / 1 h / Heating / reflux

5.1: sodium tetrahydroborate / methanol / 1.5 h / 0 - 20 °C

5.2: 0 °C

6.1: trifluoroacetic acid / dichloromethane / 20 h / 0 - 20 °C

7.1: Resolution of racemate

8.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

8.2: 0 °C

9.1: triethylamine / dichloromethane / 1 h / 0 °C

10.1: dimethyl sulfoxide / 13 h / 50 °C

11.1: sodium hydroxide; water; isopropyl alcohol / 24 h / Heating / reflux

11.2: 0 °C

12.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C

13.1: potassium carbonate

With manganese(IV) oxide; sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; n-butyllithium; water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; isopropyl alcohol; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; dimethyl sulfoxide; toluene;