(3-((3-bromoprop-2-yn-1-yl)oxy)prop-1-yn-1-yl)benzene

Base Information

• Chemical Name: (3-((3-bromoprop-2-yn-1-yl)oxy)prop-1-yn-1-yl)benzene
• CAS No.: 1574562-16-5
• Molecular Formula: C₁₂H₉BrO
• Molecular Weight: 249.107
• Mol file: 1574562-16-5.mol

Synonyms:(3-((3-bromoprop-2-yn-1-yl)oxy)prop-1-yn-1-yl)benzene

Chemical Property of (3-((3-bromoprop-2-yn-1-yl)oxy)prop-1-yn-1-yl)benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3-((3-bromoprop-2-yn-1-yl)oxy)prop-1-yn-1-yl)benzene

There total 3 articles about (3-((3-bromoprop-2-yn-1-yl)oxy)prop-1-yn-1-yl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(3-(prop-2-ynyloxy)prop-1-ynyl)benzene (53877-63-7) → (3-((3-bromoprop-2-yn-1-yl)oxy)prop-1-yn-1-yl)benzene (1574562-16-5)

Guidance literature:

With N-Bromosuccinimide; silver nitrate; In acetone; at 20 ℃; for 5h;

DOI:10.1021/acs.orglett.1c02360

Reference yield: 33.0%

iodobenzene (591-50-4) + dipropargyl ether (6921-27-3) → (3-((3-bromoprop-2-yn-1-yl)oxy)prop-1-yn-1-yl)benzene (1574562-16-5)

Guidance literature:

iodobenzene; dipropargyl ether; With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diethylamine; In tetrahydrofuran; at 20 ℃; for 4h; Inert atmosphere;

With N-Bromosuccinimide; silver nitrate; In acetone; at 20 ℃; for 5h;

DOI:10.1002/adsc.201600127

Reference yield:

3-Phenyl-2-propyn-1-ol (1504-58-1) → (3-((3-bromoprop-2-yn-1-yl)oxy)prop-1-yn-1-yl)benzene (1574562-16-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

1.2: 0.08 h / 20 °C / Inert atmosphere

2.1: N-Bromosuccinimide; silver nitrate / acetone / 5 h / 20 °C

With N-Bromosuccinimide; sodium hydride; silver nitrate; In tetrahydrofuran; acetone;

DOI:10.1021/acs.orglett.1c02360

upstream raw materials:

iodobenzene

dipropargyl ether

3-Phenyl-2-propyn-1-ol

(3-(prop-2-ynyloxy)prop-1-ynyl)benzene

Downstream raw materials:

C₁₇H₁₄BrNOS

C₂₃H₁₉NOS