methyl 2-ethoxy-1-<<2'-biphenyl-4-yl>methyl>-1H-benzimidazole-5-carboxylate

Base Information

• Chemical Name: methyl 2-ethoxy-1-<<2'-biphenyl-4-yl>methyl>-1H-benzimidazole-5-carboxylate
• CAS No.: 150058-30-3
• Molecular Formula: C₄₄H₃₆N₆O₃
• Molecular Weight: 696.808
• Mol file: 150058-30-3.mol

Synonyms:methyl 2-ethoxy-1-<<2'-biphenyl-4-yl>methyl>-1H-benzimidazole-5-carboxylate

Chemical Property of methyl 2-ethoxy-1-<<2'-biphenyl-4-yl>methyl>-1H-benzimidazole-5-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-ethoxy-1-<<2'-biphenyl-4-yl>methyl>-1H-benzimidazole-5-carboxylate

There total 2 articles about methyl 2-ethoxy-1-<<2'-biphenyl-4-yl>methyl>-1H-benzimidazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Methyl 3,4-diaminobenzoate (36692-49-6) → methyl 2-ethoxy-1-<<2'-biphenyl-4-yl>methyl>-1H-benzimidazole-5-carboxylate (150058-30-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 39 percent / acetic acid / 4 h / 90 - 100 °C

2: 1.) NaH / 1.) DMF, 0 deg C, 15 min, 2.) DMF, RT, 3 h

With sodium hydride; acetic acid;

DOI:10.1021/jm00067a016

Reference yield:

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole (124750-51-2) + 2-ethoxyl-1H-benzimidazole-5-carboxylic acid methyl ester (150058-28-9) → methyl 2-ethoxy-1-<<2'-biphenyl-4-yl>methyl>-1H-benzimidazole-6-carboxylate (150058-31-4) + methyl 2-ethoxy-1-<<2'-biphenyl-4-yl>methyl>-1H-benzimidazole-5-carboxylate (150058-30-3)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction. Yields of byproduct given; 1.) DMF, 0 deg C, 15 min, 2.) DMF, RT, 3 h;

DOI:10.1021/jm00067a016

Reference yield: 60.0%

methyl 2-ethoxy-1-<<2'-biphenyl-4-yl>methyl>-1H-benzimidazole-5-carboxylate (150058-30-3) → 2-Ethoxy-1-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1H-benzoimidazole-5-carboxylic acid methyl ester (150058-34-7)

Guidance literature:

With hydrogenchloride; In methanol; chloroform; at 0 - 5 ℃; for 4h;

DOI:10.1021/jm00067a016

upstream raw materials:

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

2-ethoxyl-1H-benzimidazole-5-carboxylic acid methyl ester

Methyl 3,4-diaminobenzoate

Downstream raw materials:

2-Ethoxy-1-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1H-benzoimidazole-5-carboxylic acid methyl ester