(R)-N-(1-(7-amino-4-(4-(morpholine-4-carbonyl)phenylamino)imidazo[1,2-f][1,2,4]triazin-2-yl)piperidin-3-yl)-4-tert-butylbenzamide

Base Information

Chemical Name:(R)-N-(1-(7-amino-4-(4-(morpholine-4-carbonyl)phenylamino)imidazo[1,2-f][1,2,4]triazin-2-yl)piperidin-3-yl)-4-tert-butylbenzamide
CAS No.:1062130-43-1
Molecular Formula:C₃₂H₃₉N₉O₃
Molecular Weight:597.72
Hs Code.:

Synonyms:(R)-N-(1-(7-amino-4-(4-(morpholine-4-carbonyl)phenylamino)imidazo[1,2-f][1,2,4]triazin-2-yl)piperidin-3-yl)-4-tert-butylbenzamide

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Chemical Property of (R)-N-(1-(7-amino-4-(4-(morpholine-4-carbonyl)phenylamino)imidazo[1,2-f][1,2,4]triazin-2-yl)piperidin-3-yl)-4-tert-butylbenzamide

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Technology Process of (R)-N-(1-(7-amino-4-(4-(morpholine-4-carbonyl)phenylamino)imidazo[1,2-f][1,2,4]triazin-2-yl)piperidin-3-yl)-4-tert-butylbenzamide

There total 11 articles about (R)-N-(1-(7-amino-4-(4-(morpholine-4-carbonyl)phenylamino)imidazo[1,2-f][1,2,4]triazin-2-yl)piperidin-3-yl)-4-tert-butylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.01%

: 1062132-59-5
(R)-4-tert-butyl-N-(piperidin-3-yl)benzamide

: 1062135-93-6
(4-(7-amino-2-(methylsulfonyl)imidazo[1,2-f][1,2,4]triazin-4-ylamino)phenyl)(morpholino)methanone

: 1062130-43-1
(R)-N-(1-(7-amino-4-(4-(morpholine-4-carbonyl)phenylamino)imidazo[1,2-f][1,2,4]triazin-2-yl)piperidin-3-yl)-4-tert-butylbenzamide

Guidance literature:: at 160 ℃; for 7h; Neat (no solvent);

Reference yield:

: 1062135-87-8
7-bromo-2,4-bis(methylthio)imidazo[2,1-f][1,2,4]triazine

: 1062130-43-1
(R)-N-(1-(7-amino-4-(4-(morpholine-4-carbonyl)phenylamino)imidazo[1,2-f][1,2,4]triazin-2-yl)piperidin-3-yl)-4-tert-butylbenzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C

1.2: 1.33 h / -78 - 20 °C

1.3: pH 5

2.1: diphenyl phosphoryl azide; N-ethyl-N,N-diisopropylamine / 3 h / Heating / reflux

3.1: potassium tert-butylate / tetrahydrofuran / 1.08 h / 20 °C

3.2: pH 9 - 10

4.1: 3-chloro-benzenecarboperoxoic acid / tetrahydrofuran / 3 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 1.03 h / 0 - 20 °C

6.1: 7 h / 160 °C / Neat (no solvent)

With n-butyllithium; diphenyl phosphoryl azide; potassium tert-butylate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

Reference yield:

: 98-73-7
4-(1,1-dimethylethyl)benzoic acid

: 1062130-43-1
(R)-N-(1-(7-amino-4-(4-(morpholine-4-carbonyl)phenylamino)imidazo[1,2-f][1,2,4]triazin-2-yl)piperidin-3-yl)-4-tert-butylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 5 h / 20 - 55 °C

2: trifluoroacetic acid / dichloromethane / 1.58 h / 0 - 20 °C

3: 7 h / 160 °C / Neat (no solvent)

With 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;