ethyl 3-(3,5-dibromo-4-hydroxyphenyl)-2(E)-(hydroxyimino)propanoate

Base Information

• Chemical Name: ethyl 3-(3,5-dibromo-4-hydroxyphenyl)-2(E)-(hydroxyimino)propanoate
• CAS No.: 181116-18-7
• Molecular Formula: C₁₁H₁₁Br₂NO₄
• Molecular Weight: 381.021
• Mol file: 181116-18-7.mol

Synonyms:ethyl 3-(3,5-dibromo-4-hydroxyphenyl)-2(E)-(hydroxyimino)propanoate

Chemical Property of ethyl 3-(3,5-dibromo-4-hydroxyphenyl)-2(E)-(hydroxyimino)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-(3,5-dibromo-4-hydroxyphenyl)-2(E)-(hydroxyimino)propanoate

There total 2 articles about ethyl 3-(3,5-dibromo-4-hydroxyphenyl)-2(E)-(hydroxyimino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

ethyl 3-(4-hydroxyphenyl)-2(E)-(hydroxyimino)propanoate (181116-17-6) → ethyl 3-(3,5-dibromo-4-hydroxyphenyl)-2(E)-(hydroxyimino)propanoate (181116-18-7)

Guidance literature:

With N-Bromosuccinimide; In tetrahydrofuran; at 0 ℃;

DOI:10.1021/jo010015v

Reference yield:

tyrosine ethyl ester (34081-17-9) → ethyl 3-(3,5-dibromo-4-hydroxyphenyl)-2(E)-(hydroxyimino)propanoate (181116-18-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / MeReO₃; 30percent H₂O₂ / ethanol / 0.25 h

2: 70 percent / NBS / tetrahydrofuran / 0 °C

With N-Bromosuccinimide; methyltrioxorhenium(VII); In tetrahydrofuran; ethanol;

DOI:10.1021/jo010015v

Reference yield: 99.0%

ethyl 3-(3,5-dibromo-4-hydroxyphenyl)-2(E)-(hydroxyimino)propanoate (181116-18-7) → (E)-3-(3,5-dibromo-4-hydroxyphenyl)-2-(hydroxyimino)propanoic acid (343256-43-9)

Guidance literature:

With potassium hydroxide; In tetrahydrofuran; water; at 20 ℃;

DOI:10.1021/jo010015v

upstream raw materials:

ethyl 3-(4-hydroxyphenyl)-2(E)-(hydroxyimino)propanoate

tyrosine ethyl ester

Downstream raw materials:

(E)-3-(3,5-dibromo-4-hydroxyphenyl)-2-(hydroxyimino)propanoic acid

2,6-dibromo-4-cyanomethylphenol