(3R)-3-(Dimethylamino)-1-[[3-[5-[[(3-chloro-4-methoxyphenyl)methyl]amino]-4,8-dihydro-8-[(4-methoxyphenyl)methyl]-4-oxo-1H-pyrazolo[4',3':5,6]pyrido[4,3-d]pyrimidin-2-yl]-4-propoxyphenyl]sulfonyl]pyrrolidine

Base Information

• Chemical Name: (3R)-3-(Dimethylamino)-1-[[3-[5-[[(3-chloro-4-methoxyphenyl)methyl]amino]-4,8-dihydro-8-[(4-methoxyphenyl)methyl]-4-oxo-1H-pyrazolo[4',3':5,6]pyrido[4,3-d]pyrimidin-2-yl]-4-propoxyphenyl]sulfonyl]pyrrolidine
• CAS No.: 459124-67-5
• Molecular Formula: C₃₉H₄₃ClN₈O₆S
• Molecular Weight: 787.339
• Mol file: 459124-67-5.mol

Synonyms:(3R)-3-(Dimethylamino)-1-[[3-[5-[[(3-chloro-4-methoxyphenyl)methyl]amino]-4,8-dihydro-8-[(4-methoxyphenyl)methyl]-4-oxo-1H-pyrazolo[4',3':5,6]pyrido[4,3-d]pyrimidin-2-yl]-4-propoxyphenyl]sulfonyl]pyrrolidine

Chemical Property of (3R)-3-(Dimethylamino)-1-[[3-[5-[[(3-chloro-4-methoxyphenyl)methyl]amino]-4,8-dihydro-8-[(4-methoxyphenyl)methyl]-4-oxo-1H-pyrazolo[4',3':5,6]pyrido[4,3-d]pyrimidin-2-yl]-4-propoxyphenyl]sulfonyl]pyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R)-3-(Dimethylamino)-1-[[3-[5-[[(3-chloro-4-methoxyphenyl)methyl]amino]-4,8-dihydro-8-[(4-methoxyphenyl)methyl]-4-oxo-1H-pyrazolo[4',3':5,6]pyrido[4,3-d]pyrimidin-2-yl]-4-propoxyphenyl]sulfonyl]pyrrolidine

There total 7 articles about (3R)-3-(Dimethylamino)-1-[[3-[5-[[(3-chloro-4-methoxyphenyl)methyl]amino]-4,8-dihydro-8-[(4-methoxyphenyl)methyl]-4-oxo-1H-pyrazolo[4',3':5,6]pyrido[4,3-d]pyrimidin-2-yl]-4-propoxyphenyl]sulfonyl]pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-chloro-4-methoxybenzylamine·HCl + (3R)-1-[[3-(5-chloro-4,8-dihydro-8-[(4-methoxyphenyl)methyl]-4-oxo-1H-pyrazolo[4',3':5,6]pyrido[4,3-d]pyrimidin-2-yl)-4-propoxyphenyl]sulfonyl]-3-(dimethylamino)pyrrolidine (384835-99-8) → (3R)-3-(Dimethylamino)-1-[[3-[5-[[(3-chloro-4-methoxyphenyl)methyl]amino]-4,8-dihydro-8-[(4-methoxyphenyl)methyl]-4-oxo-1H-pyrazolo[4',3':5,6]pyrido[4,3-d]pyrimidin-2-yl]-4-propoxyphenyl]sulfonyl]pyrrolidine (459124-67-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In methanol; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; butan-1-ol;

Reference yield:

4-amino-6-chloro-2-(4-methoxy-benzyl)-2H-pyrazolo[3,4-b]pyridine-5-carboxylic acid (384835-97-6) → 5-(3-chloro-4-methoxy-benzylamino)-8-[5-(3-dimethylamino-pyrrolidine-1-sulfonyl)-2-propoxy-phenyl]-2-(4-methoxy-benzyl)-2,7-dihydro-2,3,4,7,9-pentaaza-cyclopenta[a]naphthalen-6-one (459124-67-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: DCC; pentafluorophenol / dimethylformamide; ethyl acetate / 0 °C

1.2: 80 percent / NH₃ / tetrahydrofuran / 20 °C

2.1: KHMDS / tetrahydrofuran / 3 h

3.1: tBuOK / 2-methyl-propan-2-ol / 1 h / 80 °C

4.1: DIEA / propan-1-ol / 4 h / Heating

With 2,3,4,5,6-pentafluorophenol; potassium tert-butylate; potassium hexamethylsilazane; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; propan-1-ol; ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1016/S0960-894X(01)00466-8

Reference yield:

4-amino-6-chloro-2-(4-methoxy-benzyl)-2H-pyrazolo[3,4-b]pyridine-5-carboxylic acid amide (384835-98-7) → 5-(3-chloro-4-methoxy-benzylamino)-8-[5-(3-dimethylamino-pyrrolidine-1-sulfonyl)-2-propoxy-phenyl]-2-(4-methoxy-benzyl)-2,7-dihydro-2,3,4,7,9-pentaaza-cyclopenta[a]naphthalen-6-one (459124-67-5)

Guidance literature:

Multi-step reaction with 3 steps

1: KHMDS / tetrahydrofuran / 3 h

2: tBuOK / 2-methyl-propan-2-ol / 1 h / 80 °C

3: DIEA / propan-1-ol / 4 h / Heating

With potassium tert-butylate; potassium hexamethylsilazane; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; propan-1-ol; tert-butyl alcohol;

DOI:10.1016/S0960-894X(01)00466-8

upstream raw materials:

(3-chloro-4-methoxyphenyl)methanamine

5-chloro-8-[5-(3-dimethylamino-pyrrolidine-1-sulfonyl)-2-propoxy-phenyl]-2-(4-methoxy-benzyl)-2,7-dihydro-2,3,4,7,9-pentaaza-cyclopenta[a]naphthalen-6-one

4-amino-6-chloro-2-(4-methoxy-benzyl)-2H-pyrazolo[3,4-b]pyridine-5-carboxylic acid

4-amino-6-chloro-2-(4-methoxy-benzyl)-2H-pyrazolo[3,4-b]pyridine-5-carboxylic acid amide

Downstream raw materials:

(3R)-1-[[3-[5-[[(3-chloro-4-methoxyphenyl)methyl]amino]-4,8-dihydro-4-oxo-1H-pyrazolo[4',3':5,6]pyrido[4,3-d]pyrimidin-2-yl]-4-propoxyphenyl]sulfonyl]-3-(dimethylamino)pyrrolidine