Boc-dl-(4-pyrimidinyl)Ala amide of (3S,4S)-1-<<(3-methylbutyl)carbonyl>amino>-3-hydroxy-4-amino-5-cyclohexylpentane

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Chemical Name:Boc-dl-(4-pyrimidinyl)Ala amide of (3S,4S)-1-<<(3-methylbutyl)carbonyl>amino>-3-hydroxy-4-amino-5-cyclohexylpentane
CAS No.:108868-82-2
Molecular Formula:C₂₉H₄₉N₅O₅
Molecular Weight:547.739
Hs Code.:

Synonyms:Boc-dl-(4-pyrimidinyl)Ala amide of (3S,4S)-1-<<(3-methylbutyl)carbonyl>amino>-3-hydroxy-4-amino-5-cyclohexylpentane

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Chemical Property of Boc-dl-(4-pyrimidinyl)Ala amide of (3S,4S)-1-<<(3-methylbutyl)carbonyl>amino>-3-hydroxy-4-amino-5-cyclohexylpentane

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Technology Process of Boc-dl-(4-pyrimidinyl)Ala amide of (3S,4S)-1-<<(3-methylbutyl)carbonyl>amino>-3-hydroxy-4-amino-5-cyclohexylpentane

There total 9 articles about Boc-dl-(4-pyrimidinyl)Ala amide of (3S,4S)-1-<<(3-methylbutyl)carbonyl>amino>-3-hydroxy-4-amino-5-cyclohexylpentane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98105-42-1
(S)-2-(t-butoxycarbonylamino)-3-cyclohexyl-1-propanal

: 108868-82-2
Boc-dl-(4-pyrimidinyl)Ala amide of (3S,4S)-1-<<(3-methylbutyl)carbonyl>amino>-3-hydroxy-4-amino-5-cyclohexylpentane

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) lithium diisopropylamide / 1.) THF, -78 deg C, 10 min, 2.) THF, -78 deg C, 15 min

2: 95 percent / H₂, NH₃ / Raney Ni / methanol / 2280 Torr

3: 91 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

4: 4 M aq. HCl / dioxane

5: N-methylmorpholine, 1-hydroxybenzotriazole monohydrate, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / 14 h / -23 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; ammonia; hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium diisopropyl amide; nickel; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00390a018

Reference yield:

: 107202-61-9
(2R,3S)-3-(t-butoxycarbonylamino)-4-cyclohexyl-1,2-epoxybutane

: 108868-82-2
Boc-dl-(4-pyrimidinyl)Ala amide of (3S,4S)-1-<<(3-methylbutyl)carbonyl>amino>-3-hydroxy-4-amino-5-cyclohexylpentane

Guidance literature:: Multi-step reaction with 5 steps

1: 65 percent / methanol; H₂O / 18 h / Ambient temperature

2: 95 percent / H₂, NH₃ / Raney Ni / methanol / 2280 Torr

3: 91 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

4: 4 M aq. HCl / dioxane

5: N-methylmorpholine, 1-hydroxybenzotriazole monohydrate, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / 14 h / -23 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; ammonia; hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; nickel; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00390a018

Reference yield:

: 108868-54-8
(3S,4S)-3-hydroxy-4-<(tert-butyloxycarbonyl)amino>-5-cyclohexylpentanenitrile

: 108868-82-2
Boc-dl-(4-pyrimidinyl)Ala amide of (3S,4S)-1-<<(3-methylbutyl)carbonyl>amino>-3-hydroxy-4-amino-5-cyclohexylpentane

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / H₂, NH₃ / Raney Ni / methanol / 2280 Torr

2: 91 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

3: 4 M aq. HCl / dioxane

4: N-methylmorpholine, 1-hydroxybenzotriazole monohydrate, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / 14 h / -23 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; ammonia; hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; nickel; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00390a018