N-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]quinoline-4-yl]oxy]phenyl]-4-(4-fluorophenyl)pyrimidine-2-carboxamide

Base Information

Chemical Name:N-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]quinoline-4-yl]oxy]phenyl]-4-(4-fluorophenyl)pyrimidine-2-carboxamide
CAS No.:1491142-25-6
Molecular Formula:C₃₄H₃₁F₂N₅O₅
Molecular Weight:627.647
Hs Code.:

Synonyms:N-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]quinoline-4-yl]oxy]phenyl]-4-(4-fluorophenyl)pyrimidine-2-carboxamide

Suppliers and Price of N-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]quinoline-4-yl]oxy]phenyl]-4-(4-fluorophenyl)pyrimidine-2-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]quinoline-4-yl]oxy]phenyl]-4-(4-fluorophenyl)pyrimidine-2-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]quinoline-4-yl]oxy]phenyl]-4-(4-fluorophenyl)pyrimidine-2-carboxamide

There total 15 articles about N-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]quinoline-4-yl]oxy]phenyl]-4-(4-fluorophenyl)pyrimidine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 479690-10-3
3-Fluoro-4-{[6-methoxy-7-(3-morpholinopropoxy)-4-quinolyl]oxy}-aniline

: C₁₁H₆ClFN₂O

: 1491142-25-6
N-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]quinoline-4-yl]oxy]phenyl]-4-(4-fluorophenyl)pyrimidine-2-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; Cooling with ice;
DOI:10.1016/j.ejmech.2013.08.019

Reference yield:

: 138716-20-8
(E)-3-(dimethylamino)-1-(4-fluorophenyl)prop-2-en-1-one

: 1491142-25-6
N-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]quinoline-4-yl]oxy]phenyl]-4-(4-fluorophenyl)pyrimidine-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium ethanolate / ethanol / 70 °C

2: sulfuric acid; dihydrogen peroxide; ferrous(II) sulfate heptahydrate / 0 - 15 °C

3: sulfuric acid / 100 °C

4: thionyl chloride / 6 h / Reflux

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Cooling with ice

With ferrous(II) sulfate heptahydrate; thionyl chloride; sulfuric acid; dihydrogen peroxide; sodium ethanolate; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane;
DOI:10.1016/j.ejmech.2013.08.019

Reference yield:

: 68049-19-4
4-(4-fluorophenyl)pyrimidine

: 1491142-25-6
N-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]quinoline-4-yl]oxy]phenyl]-4-(4-fluorophenyl)pyrimidine-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid; dihydrogen peroxide; ferrous(II) sulfate heptahydrate / 0 - 15 °C

2: sulfuric acid / 100 °C

3: thionyl chloride / 6 h / Reflux

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Cooling with ice

With ferrous(II) sulfate heptahydrate; thionyl chloride; sulfuric acid; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/j.ejmech.2013.08.019