3-(4-CHLOROPHENYL)-2-OXOPROPANOIC ACID

Base Information

• Chemical Name: 3-(4-CHLOROPHENYL)-2-OXOPROPANOIC ACID
• CAS No.: 3617-01-4
• Molecular Formula: C9H7 Cl O3
• Molecular Weight: 198.606
• Hs Code.: 2918300090
• Mol file: 3617-01-4.mol

Synonyms:Pyruvicacid, (p-chlorophenyl)- (7CI,8CI); (4-Chlorophenyl)pyruvic acid;(p-Chlorophenyl)pyruvic acid; 3-(4-Chlorophenyl)-2-oxopropanoic acid;3-(p-Chlorophenyl)-2-oxopropionic acid

Chemical Property of 3-(4-CHLOROPHENYL)-2-OXOPROPANOIC ACID

Chemical Property:

• Vapor Pressure: 6.06E-05mmHg at 25°C
• Refractive Index: 1.572
• Boiling Point: 331.8°C at 760 mmHg
• Flash Point: 154.5°C
• PSA: 54.37000
• Density: 1.394g/cm³
• LogP: 1.53620

Purity/Quality:

98%min ^*data from raw suppliers

3-(4-Chlorophenyl)-2-oxopropanoic acid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-(4-Chlorophenyl)-2-hydroxy-acrylic Acid is used in preparation of Pyridopyrazinone derivatives as insulin secretion stimulators useful for treating diabetes.

Technology Process of 3-(4-CHLOROPHENYL)-2-OXOPROPANOIC ACID

There total 22 articles about 3-(4-CHLOROPHENYL)-2-OXOPROPANOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

5-[1-(4-Chloro-phenyl)-meth-(Z)-ylidene]-2-trichloromethyl-[1,3]dioxolan-4-one (127220-32-0,127220-40-0) → β-(4-chlorophenyl)pyruvic acid (3617-01-4)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; for 5h; Ambient temperature;

DOI:10.1055/s-1989-27439

Reference yield: 78.0%

DL-Phe(4Cl) (7424-00-2,1991-78-2) → para-Chloro-D-phenylalanine (14091-08-8,1991-78-2) + β-(4-chlorophenyl)pyruvic acid (3617-01-4)

Guidance literature:

With diaphorase; 2,6-Dichlorophenolindophenol; potassium chloride; oxygen; nicotiamide adenine dinucleotide; at 15 - 20 ℃; pH=9.5; aq. buffer; Enzymatic reaction;

DOI:10.1039/b809147a

Reference yield: 77.3%

2-acetamido-3-(4-chlorophenyl)acrylic acid (88681-63-4,3617-00-3) → β-(4-chlorophenyl)pyruvic acid (3617-01-4)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; for 10h; Heating / reflux;

upstream raw materials:

4-(4-chloro-benzyl)-2-trifluoromethyl-4H-oxazol-5-one

2-[Chloro-(4-chloro-phenyl)-methyl]-2-hydroxy-malonic acid

(Z)-2-phenyl-4-(4-chlorobenzylidene)-5(4H)-oxazolone

(Z/E)-4-(4-chlorobenzylidene)-2-phenyl-1,3-oxazol-5(4H)-one

Downstream raw materials:

3-(4-chloro-phenyl)-2-(4-oxo-2-thioxo-thiazolidin-5-ylidene)-propionic acid

(E)-N-[2-(4-Chlorophenyl)ethenyl]morpholine

4-Amino-6-(4-chloro-benzyl)-2H-[1,2,4]triazine-3,5-dione

6-(4-Chloro-benzyl)-3-mercapto-2H-[1,2,4]triazin-5-one

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