(E)-1-(7-Bromo-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-3-(4-dimethylamino-phenyl)-propenone

Base Information

Chemical Name:(E)-1-(7-Bromo-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-3-(4-dimethylamino-phenyl)-propenone
CAS No.:179694-25-8
Molecular Formula:C₂₈H₂₉BrN₂O₂
Molecular Weight:505.454
Hs Code.:

Synonyms:(E)-1-(7-Bromo-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-3-(4-dimethylamino-phenyl)-propenone

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Chemical Property of (E)-1-(7-Bromo-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-3-(4-dimethylamino-phenyl)-propenone

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Technology Process of (E)-1-(7-Bromo-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-3-(4-dimethylamino-phenyl)-propenone

There total 1 articles about (E)-1-(7-Bromo-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-3-(4-dimethylamino-phenyl)-propenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1552-96-1
4-dimethylaminocinnamic acid

: 73894-40-3
(+/-)-7-bromo-8-methoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

: 179694-25-8
(E)-1-(7-Bromo-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-3-(4-dimethylamino-phenyl)-propenone

Guidance literature:: With 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; for 18h; Ambient temperature;
DOI:10.1021/jm960143p

Reference yield: 85.0%

: 179694-25-8
(E)-1-(7-Bromo-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-3-(4-dimethylamino-phenyl)-propenone

: 179694-27-0
{4-[(E)-3-(7-Bromo-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-propenyl]-phenyl}-dimethyl-amine

Guidance literature:: With lithium aluminium tetrahydride; sulfuric acid; In tetrahydrofuran; for 2h; Ambient temperature;
DOI:10.1021/jm960143p

Reference yield:

: 179694-25-8
(E)-1-(7-Bromo-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-3-(4-dimethylamino-phenyl)-propenone

: 8-Bromo-3-[(E)-3-(4-dimethylamino-phenyl)-allyl]-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / LiAlH₄, 98percent H₂SO₄ / tetrahydrofuran / 2 h / Ambient temperature

2: 70 percent / BBr₃ / CHCl₃; CH₂Cl₂ / 1 h / Ambient temperature

With lithium aluminium tetrahydride; sulfuric acid; boron tribromide; In tetrahydrofuran; dichloromethane; chloroform;
DOI:10.1021/jm960143p