Technology Process of (2,4-dichloro-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(pyrimidin-5-yl)methanol
There total 9 articles about (2,4-dichloro-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(pyrimidin-5-yl)methanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
6-bromo-2,4-dichloro-3-phenylquinoline; (1-methyl-1H-imidazol-5-yl)(pyrimidin-5-yl)methanone;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at 20 ℃;
for 1.5h;
Inert atmosphere;
Cooling with acetone-dry ice;
With
water; ammonium chloride;
In
tetrahydrofuran; hexane;
Inert atmosphere;
Cooling with acetone-dry ice;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran; hexane; water / 4 h / -78 - 20 °C
2.1: trichlorophosphate / 3.5 h / 107 °C
3.1: n-butyllithium / tetrahydrofuran; hexane / 1.5 h / 20 °C / Inert atmosphere; Cooling with acetone-dry ice
3.2: Inert atmosphere; Cooling with acetone-dry ice
With
n-butyllithium; lithium hexamethyldisilazane; trichlorophosphate;
In
tetrahydrofuran; hexane; water;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: trichlorophosphate / 3.5 h / 107 °C
2.1: n-butyllithium / tetrahydrofuran; hexane / 1.5 h / 20 °C / Inert atmosphere; Cooling with acetone-dry ice
2.2: Inert atmosphere; Cooling with acetone-dry ice
With
n-butyllithium; trichlorophosphate;
In
tetrahydrofuran; hexane;
