3-((4-(2-(hydroxymethyl)-1-methyl-1H-benzo[d]imidazol-5-yl)thiazol-2-yl)amino)-4-isopropoxybenzenesulfonamide

Base Information

Chemical Name:3-((4-(2-(hydroxymethyl)-1-methyl-1H-benzo[d]imidazol-5-yl)thiazol-2-yl)amino)-4-isopropoxybenzenesulfonamide
CAS No.:1378023-06-3
Molecular Formula:C₂₁H₂₃N₅O₄S₂
Molecular Weight:473.577
Hs Code.:

Synonyms:3-((4-(2-(hydroxymethyl)-1-methyl-1H-benzo[d]imidazol-5-yl)thiazol-2-yl)amino)-4-isopropoxybenzenesulfonamide

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Chemical Property of 3-((4-(2-(hydroxymethyl)-1-methyl-1H-benzo[d]imidazol-5-yl)thiazol-2-yl)amino)-4-isopropoxybenzenesulfonamide

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Technology Process of 3-((4-(2-(hydroxymethyl)-1-methyl-1H-benzo[d]imidazol-5-yl)thiazol-2-yl)amino)-4-isopropoxybenzenesulfonamide

There total 6 articles about 3-((4-(2-(hydroxymethyl)-1-methyl-1H-benzo[d]imidazol-5-yl)thiazol-2-yl)amino)-4-isopropoxybenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1377582-43-8
4-isopropoxy-3-thioureido-benzenesulfonamide

: 2-bromo-1-(2-(hydroxymethyl)-1-methyl-1H-benzo[d]imidazol-5-yl)ethanone hydrobromide

: 1378023-06-3
3-((4-(2-(hydroxymethyl)-1-methyl-1H-benzo[d]imidazol-5-yl)thiazol-2-yl)amino)-4-isopropoxybenzenesulfonamide

Guidance literature:: 4-isopropoxy-3-thioureido-benzenesulfonamide; 2-bromo-1-(2-(hydroxymethyl)-1-methyl-1H-benzo[d]imidazol-5-yl)ethanone hydrobromide; In ethanol; at 88 ℃; for 0.75h;

With ammonia; In methanol; ethanol; Cooling;

Reference yield:

: 406233-31-6
4-fluoro-3-nitrobenzenesulfonamide

: 1378023-06-3
3-((4-(2-(hydroxymethyl)-1-methyl-1H-benzo[d]imidazol-5-yl)thiazol-2-yl)amino)-4-isopropoxybenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium / 2.5 h / Reflux

1.2: 3.67 h / 20 °C

2.1: sodium tetrahydroborate; methanol; nickel(II) chloride hexahydrate / 0.5 h / 0 - 23 °C

3.1: sodium carbonate / chloroform; water / 1.5 h / 20 °C

4.1: ammonia / methanol / 18 h / 20 °C

5.1: ethanol / 0.75 h / 88 °C

5.2: Cooling

With methanol; sodium tetrahydroborate; nickel(II) chloride hexahydrate; ammonia; sodium; sodium carbonate; In methanol; ethanol; chloroform; water;

Reference yield:

: 1493-27-2,127723-77-7
ortho-nitrofluorobenzene

: 1378023-06-3
3-((4-(2-(hydroxymethyl)-1-methyl-1H-benzo[d]imidazol-5-yl)thiazol-2-yl)amino)-4-isopropoxybenzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: chlorosulfonic acid / 18 h / 95 °C / Reflux

1.2: 1.5 h / -35 - 20 °C

2.1: sodium / 2.5 h / Reflux

2.2: 3.67 h / 20 °C

3.1: sodium tetrahydroborate; methanol; nickel(II) chloride hexahydrate / 0.5 h / 0 - 23 °C

4.1: sodium carbonate / chloroform; water / 1.5 h / 20 °C

5.1: ammonia / methanol / 18 h / 20 °C

6.1: ethanol / 0.75 h / 88 °C

6.2: Cooling

With methanol; chlorosulfonic acid; sodium tetrahydroborate; nickel(II) chloride hexahydrate; ammonia; sodium; sodium carbonate; In methanol; ethanol; chloroform; water;