(S)-5-(3-(1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-inden-4-yl)-1,2,4-thiadiazol-5-yl)-2-isopropoxybenzonitrile hydrochloride

Base Information

Chemical Name:(S)-5-(3-(1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-inden-4-yl)-1,2,4-thiadiazol-5-yl)-2-isopropoxybenzonitrile hydrochloride
CAS No.:1413605-81-8
Molecular Formula:C₂₃H₂₄N₄O₂S*ClH
Molecular Weight:456.996
Hs Code.:

Synonyms:(S)-5-(3-(1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-inden-4-yl)-1,2,4-thiadiazol-5-yl)-2-isopropoxybenzonitrile hydrochloride

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Chemical Property of (S)-5-(3-(1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-inden-4-yl)-1,2,4-thiadiazol-5-yl)-2-isopropoxybenzonitrile hydrochloride

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Technology Process of (S)-5-(3-(1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-inden-4-yl)-1,2,4-thiadiazol-5-yl)-2-isopropoxybenzonitrile hydrochloride

There total 8 articles about (S)-5-(3-(1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-inden-4-yl)-1,2,4-thiadiazol-5-yl)-2-isopropoxybenzonitrile hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: (S)-5-(3-(1-((2-((tert-butyldimethylsilyl)oxy)ethyl)amino)-2,3-dihydro-1H-inden-4-yl)-1,2,4-thiadiazol-5-yl)-2-isopropoxybenzonitrile

: 1413605-81-8
(S)-5-(3-(1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-inden-4-yl)-1,2,4-thiadiazol-5-yl)-2-isopropoxybenzonitrile hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 4h;

Reference yield:

: 1307231-21-5
(S)-tert-butyl 4-bromo-2,3-dihydro-1H-inden-1-ylcarbamate

: 1413605-81-8
(S)-5-(3-(1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-inden-4-yl)-1,2,4-thiadiazol-5-yl)-2-isopropoxybenzonitrile hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 8 h / 85 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate tribasic trihydrate / water; N,N-dimethyl-formamide / 5 h / 100 °C / Inert atmosphere

3: hydrogenchloride / 1,4-dioxane / 3.5 h / 55 °C

4: potassium carbonate; tetra-(n-butyl)ammonium iodide / acetonitrile / 16 h / 85 °C

5: hydrogenchloride / 1,4-dioxane / 4 h / 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium phosphate tribasic trihydrate; potassium acetate; tetra-(n-butyl)ammonium iodide; potassium carbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1307231-22-6
(S)-tert-butyl (4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-inden-1-yl)carbamate

: 1413605-81-8
(S)-5-(3-(1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-inden-4-yl)-1,2,4-thiadiazol-5-yl)-2-isopropoxybenzonitrile hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate tribasic trihydrate / water; N,N-dimethyl-formamide / 5 h / 100 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane / 3.5 h / 55 °C

3: potassium carbonate; tetra-(n-butyl)ammonium iodide / acetonitrile / 16 h / 85 °C

4: hydrogenchloride / 1,4-dioxane / 4 h / 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate tribasic trihydrate; tetra-(n-butyl)ammonium iodide; potassium carbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile;