{4-(4-methoxyphenoxy)-2-[2-(4-methoxyphenyl)vinyl]-pyrimidin-5-yl}-pyrrolidin-2-(S)-ylmethylamine

Base Information

Chemical Name:{4-(4-methoxyphenoxy)-2-[2-(4-methoxyphenyl)vinyl]-pyrimidin-5-yl}-pyrrolidin-2-(S)-ylmethylamine
CAS No.:1297930-10-9
Molecular Formula:C₂₅H₂₈N₄O₃
Molecular Weight:432.522
Hs Code.:

Synonyms:{4-(4-methoxyphenoxy)-2-[2-(4-methoxyphenyl)vinyl]-pyrimidin-5-yl}-pyrrolidin-2-(S)-ylmethylamine

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Chemical Property of {4-(4-methoxyphenoxy)-2-[2-(4-methoxyphenyl)vinyl]-pyrimidin-5-yl}-pyrrolidin-2-(S)-ylmethylamine

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Technology Process of {4-(4-methoxyphenoxy)-2-[2-(4-methoxyphenyl)vinyl]-pyrimidin-5-yl}-pyrrolidin-2-(S)-ylmethylamine

There total 7 articles about {4-(4-methoxyphenoxy)-2-[2-(4-methoxyphenyl)vinyl]-pyrimidin-5-yl}-pyrrolidin-2-(S)-ylmethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1297931-11-3
2-(S)-({4-(4-methoxyphenoxy)-2-[2-(4-methoxyphenyl)vinyl]-pyrimidin-5-ylamino}-methyl)pyrrolidine-1-carboxylic acid tert-butyl ester

: 1297930-10-9
{4-(4-methoxyphenoxy)-2-[2-(4-methoxyphenyl)vinyl]-pyrimidin-5-yl}-pyrrolidin-2-(S)-ylmethylamine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 150-76-5
4-methoxy-phenol

: 1297930-10-9
{4-(4-methoxyphenoxy)-2-[2-(4-methoxyphenyl)vinyl]-pyrimidin-5-yl}-pyrrolidin-2-(S)-ylmethylamine

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydrogencarbonate / water; acetone / 0 - 20 °C

2: acetic acid; iron / methanol / 2.5 h / 65 °C

3: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 16 h / 20 °C / Inert atmosphere

4: triphenylphosphine; sodium hydrogencarbonate / palladium diacetate / N,N-dimethyl-formamide / 16 h / 130 °C

5: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With sodium tris(acetoxy)borohydride; iron; sodium hydrogencarbonate; acetic acid; triphenylphosphine; trifluoroacetic acid; palladium diacetate; In methanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1297931-00-0
2-chloro-4-(4-methoxyphenoxy)-5-nitropyrimidine

: 1297930-10-9
{4-(4-methoxyphenoxy)-2-[2-(4-methoxyphenyl)vinyl]-pyrimidin-5-yl}-pyrrolidin-2-(S)-ylmethylamine

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid; iron / methanol / 2.5 h / 65 °C

2: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 16 h / 20 °C / Inert atmosphere

3: triphenylphosphine; sodium hydrogencarbonate / palladium diacetate / N,N-dimethyl-formamide / 16 h / 130 °C

4: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With sodium tris(acetoxy)borohydride; iron; sodium hydrogencarbonate; acetic acid; triphenylphosphine; trifluoroacetic acid; palladium diacetate; In methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;