((13S)-{2-[(4-acetylamino-benzenesulfonyl)-(3-methylbutyl)-amino]-(1R)-hydroxy-ethyl}-(10S)-butyl-8,11-dioxo-2-oxa-9,12-diaza-bicyclo[13.2.2]nonadeca-1⁽¹⁸⁾,15⁽¹⁹⁾,16-trien-(7S)-yl)-carbamic acid tert-butyl ester

Base Information

• Chemical Name: ((13S)-{2-[(4-acetylamino-benzenesulfonyl)-(3-methylbutyl)-amino]-(1R)-hydroxy-ethyl}-(10S)-butyl-8,11-dioxo-2-oxa-9,12-diaza-bicyclo[13.2.2]nonadeca-1⁽¹⁸⁾,15⁽¹⁹⁾,16-trien-(7S)-yl)-carbamic acid tert-butyl ester
• CAS No.: 398526-30-2
• Molecular Formula: C₄₀H₆₁N₅O₉S
• Molecular Weight: 788.018

Synonyms:((13S)-{2-[(4-acetylamino-benzenesulfonyl)-(3-methylbutyl)-amino]-(1R)-hydroxy-ethyl}-(10S)-butyl-8,11-dioxo-2-oxa-9,12-diaza-bicyclo[13.2.2]nonadeca-1⁽¹⁸⁾,15⁽¹⁹⁾,16-trien-(7S)-yl)-carbamic acid tert-butyl ester

Chemical Property of ((13S)-{2-[(4-acetylamino-benzenesulfonyl)-(3-methylbutyl)-amino]-(1R)-hydroxy-ethyl}-(10S)-butyl-8,11-dioxo-2-oxa-9,12-diaza-bicyclo[13.2.2]nonadeca-1⁽¹⁸⁾,15⁽¹⁹⁾,16-trien-(7S)-yl)-carbamic acid tert-butyl ester

Chemical Property:

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Technology Process of ((13S)-{2-[(4-acetylamino-benzenesulfonyl)-(3-methylbutyl)-amino]-(1R)-hydroxy-ethyl}-(10S)-butyl-8,11-dioxo-2-oxa-9,12-diaza-bicyclo[13.2.2]nonadeca-1⁽¹⁸⁾,15⁽¹⁹⁾,16-trien-(7S)-yl)-carbamic acid tert-butyl ester

There total 9 articles about ((13S)-{2-[(4-acetylamino-benzenesulfonyl)-(3-methylbutyl)-amino]-(1R)-hydroxy-ethyl}-(10S)-butyl-8,11-dioxo-2-oxa-9,12-diaza-bicyclo[13.2.2]nonadeca-1⁽¹⁸⁾,15⁽¹⁹⁾,16-trien-(7S)-yl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

p-acetylaminobenzenesulfonyl chloride (121-60-8) + {(7S,10S,13S)-10-Butyl-13-[(R)-1-hydroxy-2-(3-methyl-butylamino)-ethyl]-8,11-dioxo-2-oxa-9,12-diaza-bicyclo[13.2.2]nonadeca-1(18),15(19),16-trien-7-yl}-carbamic acid tert-butyl ester → ((13S)-{2-[(4-acetylamino-benzenesulfonyl)-(3-methylbutyl)-amino]-(1R)-hydroxy-ethyl}-(10S)-butyl-8,11-dioxo-2-oxa-9,12-diaza-bicyclo[13.2.2]nonadeca-1(18),15(19),16-trien-(7S)-yl)-carbamic acid tert-butyl ester (398526-30-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; at 20 ℃; for 0.5h;

DOI:10.1021/jm010414i

Reference yield:

(7S,10S,13S)-7-tert-Butoxycarbonylamino-10-butyl-8,11-dioxo-2-oxa-9,12-diaza-bicyclo[13.2.2]nonadeca-1(18),15(19),16-triene-13-carboxylic acid methyl ester → ((13S)-{2-[(4-acetylamino-benzenesulfonyl)-(3-methylbutyl)-amino]-(1R)-hydroxy-ethyl}-(10S)-butyl-8,11-dioxo-2-oxa-9,12-diaza-bicyclo[13.2.2]nonadeca-1(18),15(19),16-trien-(7S)-yl)-carbamic acid tert-butyl ester (398526-30-2)

Guidance literature:

Multi-step reaction with 8 steps

1: 55 percent / aq. NaOH / methanol / 1 h / 0 °C

2: N-methylmorpholine / tetrahydrofuran / 0.25 h / -15 °C

3: tetrahydrofuran; diethyl ether / 0.5 h

4: 90 percent / HBr / ethyl acetate; tetrahydrofuran / -10 °C

5: 51 percent / NaBH₄ / ethanol / 0.08 h / -15 °C

6: 93 percent / NaOMe / tetrahydrofuran; methanol / 0.25 h / 20 °C

7: 85 percent / DIPEA / ethanol / Heating

8: 55 percent / DIPEA / tetrahydrofuran; H₂O / 0.5 h / 20 °C

With 4-methyl-morpholine; sodium hydroxide; sodium tetrahydroborate; hydrogen bromide; sodium methylate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; diethyl ether; ethanol; water; ethyl acetate;

DOI:10.1021/jm010414i

Reference yield:

[(7S,10S,13S)-13-(2-Bromo-acetyl)-10-butyl-8,11-dioxo-2-oxa-9,12-diaza-bicyclo[13.2.2]nonadeca-1(18),15(19),16-trien-7-yl]-carbamic acid tert-butyl ester → ((13S)-{2-[(4-acetylamino-benzenesulfonyl)-(3-methylbutyl)-amino]-(1R)-hydroxy-ethyl}-(10S)-butyl-8,11-dioxo-2-oxa-9,12-diaza-bicyclo[13.2.2]nonadeca-1(18),15(19),16-trien-(7S)-yl)-carbamic acid tert-butyl ester (398526-30-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 51 percent / NaBH₄ / ethanol / 0.08 h / -15 °C

2: 93 percent / NaOMe / tetrahydrofuran; methanol / 0.25 h / 20 °C

3: 85 percent / DIPEA / ethanol / Heating

4: 55 percent / DIPEA / tetrahydrofuran; H₂O / 0.5 h / 20 °C

With sodium tetrahydroborate; sodium methylate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; ethanol; water;

DOI:10.1021/jm010414i

upstream raw materials:

p-acetylaminobenzenesulfonyl chloride

1-amino-3-methylbutane

L-Tyr-OMe

(S)-2-((S)-2-Amino-hexanoylamino)-3-(4-hydroxy-phenyl)-propionic acid methyl ester

Downstream raw materials:

4-amino-N-[2-((7S)-amino-(10S)-butyl-8,11-dioxo-2-oxa-9,12-diaza-bicyclo[13.2.2]nonadeca-1⁽¹⁸⁾,15⁽¹⁹⁾,16-trien-(13S)-yl)-(2R)-hydroxy-ethyl]-N-(3-methyl-butyl)benzenesulfonamide

[1-((13S)-{2-[(4-acetylamino-benzenesulfonyl)-(3-methylbutyl)-amino]-(1R)-hydroxy-ethyl}-(10S)-butyl-8,11-dioxo-2-oxa-9,12-diaza-bicyclo[13.2.2]nonadeca-1⁽¹⁸⁾,15⁽¹⁹⁾,16-trien-(7S)-ylcarbamoyl)-(2S)-hydroxy-ethyl]-carbamic acid tert-butyl ester

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