(2S)-2-[((S)-[3,5-bis(trifluoromethyl)phenyl]hydroxy)methyl]but-3-enehydrazide

Base Information

Chemical Name:(2S)-2-[((S)-[3,5-bis(trifluoromethyl)phenyl]hydroxy)methyl]but-3-enehydrazide
CAS No.:1432054-83-5
Molecular Formula:C₁₃H₁₂F₆N₂O₂
Molecular Weight:342.241
Hs Code.:

Synonyms:(2S)-2-[((S)-[3,5-bis(trifluoromethyl)phenyl]hydroxy)methyl]but-3-enehydrazide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-2-[((S)-[3,5-bis(trifluoromethyl)phenyl]hydroxy)methyl]but-3-enehydrazide

Chemical Property:

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Technology Process of (2S)-2-[((S)-[3,5-bis(trifluoromethyl)phenyl]hydroxy)methyl]but-3-enehydrazide

There total 1 articles about (2S)-2-[((S)-[3,5-bis(trifluoromethyl)phenyl]hydroxy)methyl]but-3-enehydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1432054-82-4
(4S)-3-{(2S)-2-[(S)-[3,5-bis(trifluoromethyl)phenyl](hydroxy)methyl]but-3-enoyl}-4-phenyl-1,3-oxazolidin-2-one

: 1432054-83-5
(2S)-2-[((S)-[3,5-bis(trifluoromethyl)phenyl]hydroxy)methyl]but-3-enehydrazide

Guidance literature:: With hydrazine; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

: 1432054-83-5
(2S)-2-[((S)-[3,5-bis(trifluoromethyl)phenyl]hydroxy)methyl]but-3-enehydrazide

: 1432054-84-6
(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-ethenyl-1,3-oxazolidin-2-one

Guidance literature:: With hydrogenchloride; tert.-butylnitrite; In 1,4-dioxane; isopropyl alcohol; at 50 ℃; for 2h;

Reference yield:

: 1432054-83-5
(2S)-2-[((S)-[3,5-bis(trifluoromethyl)phenyl]hydroxy)methyl]but-3-enehydrazide

: 1432054-90-4
(1R,5S,7aS)-1-[3,5-bis(trifluoromethyl)phenyl]-5-[2-bromo-5-(trifluoromethyl)phenyl]tetrahydro-1H-pyrrolo[1,2-c][1,3]oxazol-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: tert.-butylnitrite; hydrogenchloride / 1,4-dioxane; isopropyl alcohol / 2 h / 50 °C

2: Helmchen dibenzo[a,e]cyclooctatetraene (dbcot) iridium phosphoramidite catalyst complex / dichloromethane / 48 h / 33 °C

3: 1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene[2-(i-propoxy)-5-(N,N-dimethylaminosulfonyl)phenyl]methyleneruthenium(II) dichloride / toluene / 2 h / 60 °C / Inert atmosphere

4: Wilkinson's catalyst; hydrogen / ethanol / 2068.65 Torr

With hydrogenchloride; Wilkinson's catalyst; tert.-butylnitrite; 1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene[2-(i-propoxy)-5-(N,N-dimethylaminosulfonyl)phenyl]methyleneruthenium(II) dichloride; hydrogen; In 1,4-dioxane; ethanol; dichloromethane; isopropyl alcohol; toluene;