Carbamic acid, [2-methyl-1-(1-methylethyl)-2-propenyl]-, 1,1-dimethylethyl

Base Information

• Chemical Name: Carbamic acid, [2-methyl-1-(1-methylethyl)-2-propenyl]-, 1,1-dimethylethyl
• CAS No.: 267668-40-6
• Molecular Formula: C₁₂H₂₃NO₂
• Molecular Weight: 213.32
• Mol file: 267668-40-6.mol

Synonyms:Carbamic acid, [2-methyl-1-(1-methylethyl)-2-propenyl]-, 1,1-dimethylethyl

Chemical Property of Carbamic acid, [2-methyl-1-(1-methylethyl)-2-propenyl]-, 1,1-dimethylethyl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Carbamic acid, [2-methyl-1-(1-methylethyl)-2-propenyl]-, 1,1-dimethylethyl

There total 3 articles about Carbamic acid, [2-methyl-1-(1-methylethyl)-2-propenyl]-, 1,1-dimethylethyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

Ph3PCH3I + (3S)-3-N-(tert-butyloxycarbonyl)amino-4-methylpentan-2-one (128211-52-9,327600-47-5) → tert-butyl (S)-4-methyl-2-oxopentan-3-ylcarbamate (1277097-39-8,267668-40-6)

Guidance literature:

Ph₃PCH₃I; With sodium hexamethyldisilazane; In tetrahydrofuran; toluene; at 0 ℃; for 0.25h; Inert atmosphere;

(3S)-3-N-(tert-butyloxycarbonyl)amino-4-methylpentan-2-one; In tetrahydrofuran; toluene; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/ol200323r

Reference yield:

N-(tert-butyloxycarbonyl) azide (1070-19-5) → N-tert-butoxycarbonyl-N-(2-methyl-1-isopropyl-2-2-propenyl)amine (267668-40-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / FeCl₂ / CH₂Cl₂ / 20 °C

2: Bu₃SnH; AIBN / benzene / 1 h / Heating

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; iron(II) chloride; In dichloromethane; benzene; 1: Rearrangement / 2: desulfurization;

DOI:10.1021/jo991569p

Reference yield:

N-tert-butyloxycarbonyl-N-(2-methyl-1-isopropyl-2-propenyl)benzenesulfenamide (267668-30-4) → (4-Methyl-2-methylene-pentyl)-carbamic acid tert-butyl ester + N-tert-butoxycarbonyl-N-(2-methyl-1-isopropyl-2-2-propenyl)amine (267668-40-6)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; for 1h; Title compound not separated from byproducts.; Heating;

DOI:10.1021/jo991569p

upstream raw materials:

N-tert-butyloxycarbonyl-N-(2-methyl-1-isopropyl-2-propenyl)benzenesulfenamide

N-(tert-butyloxycarbonyl) azide

(3S)-3-N-(tert-butyloxycarbonyl)amino-4-methylpentan-2-one