methyl ((Z)-2-((S)-2-((tert-butoxycarbonyl)amino)propanamido)-3-phenylacryloyl)-L-alaninate

Base Information

Chemical Name:methyl ((Z)-2-((S)-2-((tert-butoxycarbonyl)amino)propanamido)-3-phenylacryloyl)-L-alaninate
CAS No.:174176-25-1
Molecular Formula:C₂₁H₂₉N₃O₆
Molecular Weight:419.478
Hs Code.:

Synonyms:methyl ((Z)-2-((S)-2-((tert-butoxycarbonyl)amino)propanamido)-3-phenylacryloyl)-L-alaninate

Suppliers and Price of methyl ((Z)-2-((S)-2-((tert-butoxycarbonyl)amino)propanamido)-3-phenylacryloyl)-L-alaninate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl ((Z)-2-((S)-2-((tert-butoxycarbonyl)amino)propanamido)-3-phenylacryloyl)-L-alaninate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl ((Z)-2-((S)-2-((tert-butoxycarbonyl)amino)propanamido)-3-phenylacryloyl)-L-alaninate

There total 7 articles about methyl ((Z)-2-((S)-2-((tert-butoxycarbonyl)amino)propanamido)-3-phenylacryloyl)-L-alaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 10065-72-2
L-Alanine methyl ester

: (S,Z)-2-(2-((tert-butoxycarbonyl)amino)propanamido)-3-phenylacrylic acid

: 174176-25-1
methyl ((Z)-2-((S)-2-((tert-butoxycarbonyl)amino)propanamido)-3-phenylacryloyl)-L-alaninate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; diisopropylamine; In dichloromethane; water; at 0 - 20 ℃; for 22h;
DOI:10.1021/acs.orglett.6b03308

Reference yield:

: 108432-32-2
Boc-L-Ala-(Z)-ΔLeu*NCA

: 174176-25-1
methyl ((Z)-2-((S)-2-((tert-butoxycarbonyl)amino)propanamido)-3-phenylacryloyl)-L-alaninate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / CH₂Cl₂ / 20 °C

2: 2-mercaptoethanol; McIlvaine buffer / papain (EC 3.4.22.2) / 24 h / 35 °C / pH 8.0

3: dicyclohexylcarbodiimide; 4-(dimethylamino)pyridine / CH₂Cl₂ / 3.3 h / -10 °C

4: triethylamine / CH₂Cl₂ / 20 °C

With dmap; McIlvaine buffer; triethylamine; dicyclohexyl-carbodiimide; 2-hydroxyethanethiol; papain (EC 3.4.22.2); In dichloromethane; 1: Condensation / 2: Hydrolysis / 3: Condensation / 4: Condensation;
DOI:10.1246/bcsj.70.1427

Reference yield:

: 193069-37-3
Boc-Ala-ΔLeu-Ala-OMe

: 174176-25-1
methyl ((Z)-2-((S)-2-((tert-butoxycarbonyl)amino)propanamido)-3-phenylacryloyl)-L-alaninate

Guidance literature:: Multi-step reaction with 3 steps

1: 2-mercaptoethanol; McIlvaine buffer / papain (EC 3.4.22.2) / 24 h / 35 °C / pH 8.0

2: dicyclohexylcarbodiimide; 4-(dimethylamino)pyridine / CH₂Cl₂ / 3.3 h / -10 °C

3: triethylamine / CH₂Cl₂ / 20 °C

With dmap; McIlvaine buffer; triethylamine; dicyclohexyl-carbodiimide; 2-hydroxyethanethiol; papain (EC 3.4.22.2); In dichloromethane; 1: Hydrolysis / 2: Condensation / 3: Condensation;
DOI:10.1246/bcsj.70.1427