2,3-DIHYDRO-1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE

Base Information

• Chemical Name: 2,3-DIHYDRO-1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE
• CAS No.: 267413-07-0
• Molecular Formula: C₈H₇N₃
• Molecular Weight: 145.164
• Mol file: 267413-07-0.mol

Synonyms:2,3-DIHYDRO-1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE;1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile,2,3-dihydro-(9CI)

Chemical Property of 2,3-DIHYDRO-1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE

Chemical Property:

• Vapor Pressure: 0.00095mmHg at 25°C
• Refractive Index: 1.615
• Boiling Point: 303.1°C at 760 mmHg
• PKA: 4.16±0.20(Predicted)
• Flash Point: 137.1°C
• PSA: 48.71000
• Density: 1.18g/cm³
• LogP: 1.05928

Purity/Quality:

98%min ^*data from raw suppliers

2,3-Dihydro-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3-DIHYDRO-1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE

There total 6 articles about 2,3-DIHYDRO-1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

potassiumhexacyanoferrate(II) trihydrate + 7-aza-5-bromoindoline (115170-40-6) → 3,4-dihydro-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile (267413-07-0)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,8-diazabicyclo[5.4.0]undec-7-ene; In water; tert-butyl alcohol; at 85 ℃; for 4h; Inert atmosphere;

DOI:10.1039/c2cc17468e

Reference yield: 69.0%

zinc(II) cyanide (557-21-1) + 7-aza-5-bromoindoline (115170-40-6) → 3,4-dihydro-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile (267413-07-0)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dimethyl sulfoxide; at 125 ℃; for 8h; Inert atmosphere;

Reference yield: 66.0%

dicyanozinc (557-21-1) + 7-aza-5-bromoindoline (115170-40-6) → 3,4-dihydro-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile (267413-07-0)

Guidance literature:

tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dimethyl sulfoxide; at 120 ℃; for 4h;

upstream raw materials:

dicyanozinc

7-aza-5-bromoindoline

5-bromo-1H-pyrrolo[2,3-b]pyridine

zinc(II) cyanide

Downstream raw materials:

5-aminomethyl-7-azaindoline

N-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-ylmethyl)-2-(6-methyl-2-oxo-3-phenethylamino-2H-pyrazin-1-yl)-acetamide

2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid