N-benzyl-1,4-dimethyl-3-cyclohexenecarboxamide

Base Information

• Chemical Name: N-benzyl-1,4-dimethyl-3-cyclohexenecarboxamide
• CAS No.: 107688-44-8
• Molecular Formula: C₁₆H₂₁NO
• Molecular Weight: 243.349
• Mol file: 107688-44-8.mol

Synonyms:N-benzyl-1,4-dimethyl-3-cyclohexenecarboxamide

Chemical Property of N-benzyl-1,4-dimethyl-3-cyclohexenecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyl-1,4-dimethyl-3-cyclohexenecarboxamide

There total 4 articles about N-benzyl-1,4-dimethyl-3-cyclohexenecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1,4-dimethylcyclohex-3-ene-1-carboxylic acid (16695-87-7) + benzylamine (100-46-9) → N-benzyl-1,4-dimethyl-3-cyclohexenecarboxamide (107688-44-8)

Guidance literature:

With oxalyl dichloride; triethylamine; In dichloromethane; Ambient temperature;

DOI:10.1016/S0040-4039(00)84207-0

Reference yield:

1,4-Dimethyl-3-cyclohexen-1-carbonsaeure-methylester (58911-05-0,23733-88-2) → N-benzyl-1,4-dimethyl-3-cyclohexenecarboxamide (107688-44-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / KOH / aq. ethanol

2: 95 percent / 1.) (COCl)2; 2.) NEt₃ / CH₂Cl₂ / Ambient temperature

With potassium hydroxide; oxalyl dichloride; triethylamine; In ethanol; dichloromethane;

DOI:10.1016/S0040-4039(00)84207-0

Reference yield:

isoprene (78-79-5,9003-31-0) → N-benzyl-1,4-dimethyl-3-cyclohexenecarboxamide (107688-44-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / AlCl₃ / benzene / 0 degC --> r.t.

2: 92 percent / KOH / aq. ethanol

3: 95 percent / 1.) (COCl)2; 2.) NEt₃ / CH₂Cl₂ / Ambient temperature

With potassium hydroxide; aluminium trichloride; oxalyl dichloride; triethylamine; In ethanol; dichloromethane; benzene;

DOI:10.1016/S0040-4039(00)84207-0

upstream raw materials:

1,4-dimethylcyclohex-3-ene-1-carboxylic acid

benzylamine

1,4-Dimethyl-cyclohexen-⁽³⁾-carbonsaeure-⁽¹⁾-chlorid

1,4-Dimethyl-3-cyclohexen-1-carbonsaeure-methylester

Downstream raw materials:

N-benzyl-2,5-dimethyl-7-azabicyclo<3.3.1>non-2-ene

N-benzyl-N-(1,4-dimethyl-3-cyclohexenyl)methylamine hydrochloride