(3R,4S)-1-Boc-4-Cbz-amino-3-pyrrolidinecarboxylic acid

Base Information

Chemical Name:(3R,4S)-1-Boc-4-Cbz-amino-3-pyrrolidinecarboxylic acid
CAS No.:267230-43-3
Molecular Formula:C18H24 N2 O6
Molecular Weight:364.39
Hs Code.:
Mol file:267230-43-3.mol

Synonyms:(3R,4S)-1-Boc-4-Cbz-amino-3-pyrrolidinecarboxylic acid

Suppliers and Price of (3R,4S)-1-Boc-4-Cbz-amino-3-pyrrolidinecarboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Labseeker
(3R,4S)-4-(benzyloxycarbonylamino)-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylicacid 95
5g
$ 1750.00

American Custom Chemicals Corporation
(3R,4S)-1-BOC-4-CBZ-AMINO-3-PYRROLIDINECARBOXYLIC ACID 95.00%
5MG
$ 495.12

Total 2 raw suppliers

Chemical Property of (3R,4S)-1-Boc-4-Cbz-amino-3-pyrrolidinecarboxylic acid

Chemical Property:

Vapor Pressure:6.07E-13mmHg at 25°C
Refractive Index:1.569
Boiling Point:550.3°Cat760mmHg
PKA:4.20±0.40(Predicted)
Flash Point:286.6°C
PSA：108.66000
Density:1.28g/cm³
LogP:2.37520

Purity/Quality:: (3R,4S)-4-(benzyloxycarbonylamino)-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylicacid 95 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (3R,4S)-1-Boc-4-Cbz-amino-3-pyrrolidinecarboxylic acid

There total 2 articles about (3R,4S)-1-Boc-4-Cbz-amino-3-pyrrolidinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 267230-42-2
(3R,4S)-4-Benzyloxycarbonylamino-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester

: 267230-43-3
(3R,4S)-4-Benzyloxycarbonylamino-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester

Guidance literature:: With lithium hydroxide; In methanol; water; at 0 ℃; for 15h;
DOI:10.1021/ja000093k

Reference yield:

: 346610-81-9,267230-41-1
(3S,4R)-1-(N-tert-butoxycarbonyl)-3-[(1'R)-phenylethylamino]pyrrolidine-4-carboxylic acid ethyl ester hydrochloride

: 267230-43-3
(3R,4S)-4-Benzyloxycarbonylamino-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: Pd/C; H₂ / ethanol / 22 h / 20 °C / 2585.81 Torr

1.2: 90 percent / NaHCO₃ / acetone; H₂O / 14 h / 20 °C

2.1: LiOH / methanol; H₂O / 15 h / 0 °C

With lithium hydroxide; palladium on activated charcoal; hydrogen; In methanol; ethanol; water; 1.1: Hydrogenolysis / 1.2: Acylation / 2.1: Hydrolysis;
DOI:10.1021/ja000093k

Reference yield: 84.0%

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 267230-43-3
(3R,4S)-4-Benzyloxycarbonylamino-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester

: 267230-44-4
(3S,4R)-1-(N-tert-butoxycarbonyl)-3-(9H-fluoren-9-yl-methoxycarbonylamino)pyrrolidine-4-carboxylic acid

Guidance literature:: (3R,4S)-4-Benzyloxycarbonylamino-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester; With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 15h; under 1810.07 Torr;

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide; With sodium hydrogencarbonate; In water; acetone; at 20 ℃; for 28h; Further stages.;
DOI:10.1021/ja000093k