(R)-3-methyl-3-(2-methylbut-3-en-2-yl)-4-phenyl-2,3-dihydro-[1,2,5]thiadiazole-1,1-dioxide

Base Information

Chemical Name:(R)-3-methyl-3-(2-methylbut-3-en-2-yl)-4-phenyl-2,3-dihydro-[1,2,5]thiadiazole-1,1-dioxide
CAS No.:1401912-21-7
Molecular Formula:C₁₄H₁₈N₂O₂S
Molecular Weight:278.375
Hs Code.:

Synonyms:(R)-3-methyl-3-(2-methylbut-3-en-2-yl)-4-phenyl-2,3-dihydro-[1,2,5]thiadiazole-1,1-dioxide

Suppliers and Price of (R)-3-methyl-3-(2-methylbut-3-en-2-yl)-4-phenyl-2,3-dihydro-[1,2,5]thiadiazole-1,1-dioxide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of (R)-3-methyl-3-(2-methylbut-3-en-2-yl)-4-phenyl-2,3-dihydro-[1,2,5]thiadiazole-1,1-dioxide

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of (R)-3-methyl-3-(2-methylbut-3-en-2-yl)-4-phenyl-2,3-dihydro-[1,2,5]thiadiazole-1,1-dioxide

There total 3 articles about (R)-3-methyl-3-(2-methylbut-3-en-2-yl)-4-phenyl-2,3-dihydro-[1,2,5]thiadiazole-1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: potassium trifluoro(3-methylbut-2-en-1-yl)borate

: 3775-21-1
3-methyl-4-phenyl-1,2,5-thiadiazole-1,1-dioxide

: 1401912-21-7
(R)-3-methyl-3-(2-methylbut-3-en-2-yl)-4-phenyl-2,3-dihydro-[1,2,5]thiadiazole-1,1-dioxide

Guidance literature:: With methanol; C₄₂H₄₀Cl₂Rh₂; In tetrahydrofuran; 1,4-dioxane; at 55 ℃; for 12h; optical yield given as %ee; stereoselective reaction; Inert atmosphere;
DOI:10.1002/anie.201204004

Reference yield:

: 556-82-1
3-methyl-2-buten-1-ol

: 1401912-21-7
(R)-3-methyl-3-(2-methylbut-3-en-2-yl)-4-phenyl-2,3-dihydro-[1,2,5]thiadiazole-1,1-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1: bis[(benzyldimethylamino)chloropalladium(II)]; toluene-4-sulfonic acid / methanol; dimethyl sulfoxide / 12 h / 50 °C

2: potassium hydrogen difluoride / methanol; water / 2 h / 20 °C

3: methanol; C₄₂H₄₀Cl₂Rh₂ / tetrahydrofuran; 1,4-dioxane / 12 h / 55 °C / Inert atmosphere

With methanol; potassium hydrogen difluoride; bis[(benzyldimethylamino)chloropalladium(II)]; C₄₂H₄₀Cl₂Rh₂; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; methanol; water; dimethyl sulfoxide;
DOI:10.1002/anie.201204004

Reference yield:

: 141550-13-2
4,4,5,5-tetramethyl-2-(3-methylbut-2-enyl)-1,3,2-dioxaborolane

: 1401912-21-7
(R)-3-methyl-3-(2-methylbut-3-en-2-yl)-4-phenyl-2,3-dihydro-[1,2,5]thiadiazole-1,1-dioxide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydrogen difluoride / methanol; water / 2 h / 20 °C

2: methanol; C₄₂H₄₀Cl₂Rh₂ / tetrahydrofuran; 1,4-dioxane / 12 h / 55 °C / Inert atmosphere

With methanol; potassium hydrogen difluoride; C₄₂H₄₀Cl₂Rh₂; In tetrahydrofuran; 1,4-dioxane; methanol; water;
DOI:10.1002/anie.201204004