N^α-tert-butyloxycarbonyl-L-β-(uracilyl-N¹)-α-alanyl-N^ε-benzyloxycarbonyl-D-lysine methyl ester

Base Information

• Chemical Name: N^α-tert-butyloxycarbonyl-L-β-(uracilyl-N¹)-α-alanyl-N^ε-benzyloxycarbonyl-D-lysine methyl ester
• CAS No.: 95691-43-3
• Molecular Formula: C₂₇H₃₇N₅O₉
• Molecular Weight: 575.619

Synonyms:N^α-tert-butyloxycarbonyl-L-β-(uracilyl-N¹)-α-alanyl-N^ε-benzyloxycarbonyl-D-lysine methyl ester

Chemical Property of N^α-tert-butyloxycarbonyl-L-β-(uracilyl-N¹)-α-alanyl-N^ε-benzyloxycarbonyl-D-lysine methyl ester

Chemical Property:

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Technology Process of N^α-tert-butyloxycarbonyl-L-β-(uracilyl-N¹)-α-alanyl-N^ε-benzyloxycarbonyl-D-lysine methyl ester

There total 2 articles about N^α-tert-butyloxycarbonyl-L-β-(uracilyl-N¹)-α-alanyl-N^ε-benzyloxycarbonyl-D-lysine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-tert-butoxycarbonylamino-3-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-propionic acid (62475-74-5) → Nα-tert-butyloxycarbonyl-L-β-(uracilyl-N1)-α-alanyl-Nε-benzyloxycarbonyl-D-lysine methyl ester (95691-43-3)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N'-dicyclohexylcarbodiimide / dimethylformamide / 1.5 h / 0 - 5 °C

2: dimethylformamide / 0-5 deg C, 30 min, then 20 deg C, 20 h

With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

Reference yield:

Nε-benzyloxycarbonyl-D-lysine methyl ester (145586-17-0) + N-Boc-β-(uracilyl-N1)-α-alanine pentafluorophenyl ester (74196-30-8) → Nα-tert-butyloxycarbonyl-L-β-(uracilyl-N1)-α-alanyl-Nε-benzyloxycarbonyl-D-lysine methyl ester (95691-43-3)

Guidance literature:

In N,N-dimethyl-formamide; Yield given; 0-5 deg C, 30 min, then 20 deg C, 20 h;

Reference yield: 94.0%

Nα-tert-butyloxycarbonyl-L-β-(uracilyl-N1)-α-alanyl-Nε-benzyloxycarbonyl-D-lysine methyl ester (95691-43-3) → Nα-tert-butyloxycarbonyl-L-β-(uracilyl-N1)-α-alanyl-Nε-benzyloxycarbonyl-D-lysine (95691-44-4)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; at 20 ℃; for 0.666667h;

upstream raw materials:

N^ε-benzyloxycarbonyl-D-lysine methyl ester

N-Boc-β-(uracilyl-N¹)-α-alanine pentafluorophenyl ester

2-tert-butoxycarbonylamino-3-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-propionic acid

Downstream raw materials:

N^α-tert-butyloxycarbonyl-L-β-(uracilyl-N¹)-α-alanyl-N^ε-benzyloxycarbonyl-D-lysine

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