Carbonic acid (E)-5-[(1S,3aS,4S,7S,7aR)-3a-(2-benzenesulfonyl-acetyl)-1-isobutyl-6,7-dimethyl-3-oxo-2,3,3a,4,7,7a-hexahydro-1H-isoindol-4-yl]-1-(1-ethoxy-vinyl)-4-methyl-pent-4-enyl ester ethyl ester

Base Information

Chemical Name:Carbonic acid (E)-5-[(1S,3aS,4S,7S,7aR)-3a-(2-benzenesulfonyl-acetyl)-1-isobutyl-6,7-dimethyl-3-oxo-2,3,3a,4,7,7a-hexahydro-1H-isoindol-4-yl]-1-(1-ethoxy-vinyl)-4-methyl-pent-4-enyl ester ethyl ester
CAS No.:123186-89-0
Molecular Formula:C₃₅H₄₉NO₈S
Molecular Weight:643.842
Hs Code.:

Carbonic acid (E)-5-[(1S,3aS,4S,7S,7aR)-3a-(2-benzenesulfonyl-acetyl)-1-isobutyl-6,7-dimethyl-3-oxo-2,3,3a,4,7,7a-hexahydro-1H-isoindol-4-yl]-1-(1-ethoxy-vinyl)-4-methyl-pent-4-enyl ester ethyl ester

Synonyms:Carbonic acid (E)-5-[(1S,3aS,4S,7S,7aR)-3a-(2-benzenesulfonyl-acetyl)-1-isobutyl-6,7-dimethyl-3-oxo-2,3,3a,4,7,7a-hexahydro-1H-isoindol-4-yl]-1-(1-ethoxy-vinyl)-4-methyl-pent-4-enyl ester ethyl ester

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Chemical Property of Carbonic acid (E)-5-[(1S,3aS,4S,7S,7aR)-3a-(2-benzenesulfonyl-acetyl)-1-isobutyl-6,7-dimethyl-3-oxo-2,3,3a,4,7,7a-hexahydro-1H-isoindol-4-yl]-1-(1-ethoxy-vinyl)-4-methyl-pent-4-enyl ester ethyl ester

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Technology Process of Carbonic acid (E)-5-[(1S,3aS,4S,7S,7aR)-3a-(2-benzenesulfonyl-acetyl)-1-isobutyl-6,7-dimethyl-3-oxo-2,3,3a,4,7,7a-hexahydro-1H-isoindol-4-yl]-1-(1-ethoxy-vinyl)-4-methyl-pent-4-enyl ester ethyl ester

There total 11 articles about Carbonic acid (E)-5-[(1S,3aS,4S,7S,7aR)-3a-(2-benzenesulfonyl-acetyl)-1-isobutyl-6,7-dimethyl-3-oxo-2,3,3a,4,7,7a-hexahydro-1H-isoindol-4-yl]-1-(1-ethoxy-vinyl)-4-methyl-pent-4-enyl ester ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 70849-69-3,30338-90-0,57258-51-2
(2E,4E)-4-methylhexa-2,4-dien-1-ol

: 123186-89-0
Carbonic acid (E)-5-[(1S,3aS,4S,7S,7aR)-3a-(2-benzenesulfonyl-acetyl)-1-isobutyl-6,7-dimethyl-3-oxo-2,3,3a,4,7,7a-hexahydro-1H-isoindol-4-yl]-1-(1-ethoxy-vinyl)-4-methyl-pent-4-enyl ester ethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 40 percent / BHT / xylene / 130 °C

2: 1.) KOH / 1.) H₂O, CH₃OH, C₆H₆, room temp., 2.) ether, CH₃OH

3: 100 percent / COCl₂, (C₂H₅)3N, DMSO / CH₂Cl₂ / -78 °C

4: 58 percent / tetrahydrofuran / -78 °C

5: 1.) n-C₄H₉Li / 1.) THF, HMPA, 0 deg C

6: 68 percent / PPTS / Ambient temperature

8: 1.) n-C₄H₉Li, DIBAL-H, 2.) PCC / 1.) THF, O deg C, 2.) CH₂Cl₂, room temp.

9: 2.) pyridine / 1.) THF, ether, -78 deg C, 2.) 0 deg C

With pyridine; potassium hydroxide; n-butyllithium; 2,6-di-tert-butyl-4-methyl-phenol; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; xylene;
DOI:10.1021/ja00203a042

Reference yield:

: 51021-87-5
N-benzyloxycarbonyl-L-leucine methyl ester

: 123186-89-0
Carbonic acid (E)-5-[(1S,3aS,4S,7S,7aR)-3a-(2-benzenesulfonyl-acetyl)-1-isobutyl-6,7-dimethyl-3-oxo-2,3,3a,4,7,7a-hexahydro-1H-isoindol-4-yl]-1-(1-ethoxy-vinyl)-4-methyl-pent-4-enyl ester ethyl ester

Guidance literature:: Multi-step reaction with 10 steps

2: 40 percent / BHT / xylene / 130 °C

3: 1.) KOH / 1.) H₂O, CH₃OH, C₆H₆, room temp., 2.) ether, CH₃OH

4: 100 percent / COCl₂, (C₂H₅)3N, DMSO / CH₂Cl₂ / -78 °C

5: 58 percent / tetrahydrofuran / -78 °C

6: 1.) n-C₄H₉Li / 1.) THF, HMPA, 0 deg C

7: 68 percent / PPTS / Ambient temperature

9: 1.) n-C₄H₉Li, DIBAL-H, 2.) PCC / 1.) THF, O deg C, 2.) CH₂Cl₂, room temp.

10: 2.) pyridine / 1.) THF, ether, -78 deg C, 2.) 0 deg C

With pyridine; potassium hydroxide; n-butyllithium; 2,6-di-tert-butyl-4-methyl-phenol; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; xylene;
DOI:10.1021/ja00203a042

Reference yield:

: 123186-83-4
(1S,3aS,4S,7S,7aR)-4-Formyl-1-isobutyl-6,7-dimethyl-3-oxo-1,2,3,4,7,7a-hexahydro-isoindole-3a-carboxylic acid methyl ester

: 123186-89-0
Carbonic acid (E)-5-[(1S,3aS,4S,7S,7aR)-3a-(2-benzenesulfonyl-acetyl)-1-isobutyl-6,7-dimethyl-3-oxo-2,3,3a,4,7,7a-hexahydro-1H-isoindol-4-yl]-1-(1-ethoxy-vinyl)-4-methyl-pent-4-enyl ester ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 58 percent / tetrahydrofuran / -78 °C

2: 1.) n-C₄H₉Li / 1.) THF, HMPA, 0 deg C

3: 68 percent / PPTS / Ambient temperature

5: 1.) n-C₄H₉Li, DIBAL-H, 2.) PCC / 1.) THF, O deg C, 2.) CH₂Cl₂, room temp.

6: 2.) pyridine / 1.) THF, ether, -78 deg C, 2.) 0 deg C

With pyridine; n-butyllithium; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; pyridinium chlorochromate; In tetrahydrofuran;
DOI:10.1021/ja00203a042