3-(4-(prop-1-yn-1-yl)phenyl)propionic acid-d5

Base Information

Chemical Name:3-(4-(prop-1-yn-1-yl)phenyl)propionic acid-d5
CAS No.:1360803-53-7
Molecular Formula:C₁₂H₁₂O₂
Molecular Weight:193.186
Hs Code.:

Synonyms:3-(4-(prop-1-yn-1-yl)phenyl)propionic acid-d5

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Chemical Property of 3-(4-(prop-1-yn-1-yl)phenyl)propionic acid-d5

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Technology Process of 3-(4-(prop-1-yn-1-yl)phenyl)propionic acid-d5

There total 11 articles about 3-(4-(prop-1-yn-1-yl)phenyl)propionic acid-d5 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1360803-51-5
3-(4-(prop-1-yn-1-yl)phenyl)propionic acid-d₅ ethyl ester

: 1360803-53-7
3-(4-(prop-1-yn-1-yl)phenyl)propionic acid-d5

Guidance literature:: With water; sodium hydroxide; In methanol; at 20 ℃; for 2h;

Reference yield:

: 1360803-41-3
(4-((trimethylsilyl)ethynyl)phenyl)methanol-d2

: 1360803-53-7
3-(4-(prop-1-yn-1-yl)phenyl)propionic acid-d5

Guidance literature:: Multi-step reaction with 9 steps

1.1: 1H-imidazole / tetrahydrofuran / 15 h / 0 - 20 °C / Inert atmosphere

2.1: potassium carbonate; methanol / 2 h / 20 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -78 °C / Inert atmosphere

3.2: 0.5 h / 20 °C / Inert atmosphere

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

5.1: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

6.1: sodium iodide / acetone / 1 h / 20 °C

7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3 h / 0 - 20 °C / Inert atmosphere

8.1: sodium chloride; water / N,N-dimethyl-formamide / 48 h / Reflux; Inert atmosphere

9.1: sodium hydroxide; water / methanol / 2 h / 20 °C

With 1H-imidazole; methanol; n-butyllithium; tetrabutyl ammonium fluoride; water; sodium hydride; potassium carbonate; triethylamine; sodium iodide; sodium chloride; sodium hydroxide; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; acetone; mineral oil;

Reference yield:

: 1360803-42-4
tert-butyldimethyl((4-((trimethylsilyl)ethynyl)-benzyl)oxy)silane-d2

: 1360803-53-7
3-(4-(prop-1-yn-1-yl)phenyl)propionic acid-d5

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate; methanol / 2 h / 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -78 °C / Inert atmosphere

2.2: 0.5 h / 20 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

5.1: sodium iodide / acetone / 1 h / 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3 h / 0 - 20 °C / Inert atmosphere

7.1: sodium chloride; water / N,N-dimethyl-formamide / 48 h / Reflux; Inert atmosphere

8.1: sodium hydroxide; water / methanol / 2 h / 20 °C

With methanol; n-butyllithium; tetrabutyl ammonium fluoride; water; sodium hydride; potassium carbonate; triethylamine; sodium iodide; sodium chloride; sodium hydroxide; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; acetone; mineral oil;