2-chloro-5-[{6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-yl}amino]benzo-1,4-quinone

Base Information

Chemical Name:2-chloro-5-[{6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-yl}amino]benzo-1,4-quinone
CAS No.:872332-22-4
Molecular Formula:C₂₂H₂₃ClN₄O₄
Molecular Weight:442.902
Hs Code.:

Synonyms:2-chloro-5-[{6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-yl}amino]benzo-1,4-quinone

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Chemical Property of 2-chloro-5-[{6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-yl}amino]benzo-1,4-quinone

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Technology Process of 2-chloro-5-[{6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-yl}amino]benzo-1,4-quinone

There total 6 articles about 2-chloro-5-[{6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-yl}amino]benzo-1,4-quinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 870961-95-8
N-(4-chloro-2,5-dimethoxyphenyl)-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine

: 872332-22-4
2-chloro-5-[{6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-yl}amino]benzo-1,4-quinone

Guidance literature:: With ammonium cerium(IV) nitrate; In acetonitrile; at 20 ℃; for 1h;
DOI:10.1021/jm050559f

Reference yield:

: 159768-48-6
4-chloro-7-fluoro-6-methoxyquinazoline

: 872332-22-4
2-chloro-5-[{6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-yl}amino]benzo-1,4-quinone

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / pyridine / 2-methyl-propan-2-ol / 24 h / Heating

2: sodium bis(trimethylsilyl)amide / tetrahydrofuran / 0.5 h / Heating

3: 6.63 g / TFA / 0.75 h / 55 - 60 °C

4: 91 percent / aq. Ce(NH₄)2(NO₃)6 / acetonitrile / 1 h / 20 °C

With pyridine; ammonium cerium(IV) nitrate; sodium hexamethyldisilazane; trifluoroacetic acid; In tetrahydrofuran; acetonitrile; tert-butyl alcohol;
DOI:10.1021/jm050559f

Reference yield:

: 870962-43-9
(4-chloro-2,5-dimethoxyphenyl)(4-methoxybenzyl)amine

: 872332-22-4
2-chloro-5-[{6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-yl}amino]benzo-1,4-quinone

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / pyridine / 2-methyl-propan-2-ol / 24 h / Heating

2: sodium bis(trimethylsilyl)amide / tetrahydrofuran / 0.5 h / Heating

3: 6.63 g / TFA / 0.75 h / 55 - 60 °C

4: 91 percent / aq. Ce(NH₄)2(NO₃)6 / acetonitrile / 1 h / 20 °C

With pyridine; ammonium cerium(IV) nitrate; sodium hexamethyldisilazane; trifluoroacetic acid; In tetrahydrofuran; acetonitrile; tert-butyl alcohol;
DOI:10.1021/jm050559f