1-<2-(2,2-dimethoxyethyl)-4-(benzyloxy)phenyl>-2-<(3-benzyloxy)phenyl>ethanone

Base Information

Chemical Name:1-<2-(2,2-dimethoxyethyl)-4-(benzyloxy)phenyl>-2-<(3-benzyloxy)phenyl>ethanone
CAS No.:233597-96-1
Molecular Formula:C₃₂H₃₂O₅
Molecular Weight:496.603
Hs Code.:

Synonyms:1-<2-(2,2-dimethoxyethyl)-4-(benzyloxy)phenyl>-2-<(3-benzyloxy)phenyl>ethanone

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Chemical Property of 1-<2-(2,2-dimethoxyethyl)-4-(benzyloxy)phenyl>-2-<(3-benzyloxy)phenyl>ethanone

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Technology Process of 1-<2-(2,2-dimethoxyethyl)-4-(benzyloxy)phenyl>-2-<(3-benzyloxy)phenyl>ethanone

There total 5 articles about 1-<2-(2,2-dimethoxyethyl)-4-(benzyloxy)phenyl>-2-<(3-benzyloxy)phenyl>ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 233597-93-8
(+/-)-1-<2-(2,2-dimethoxyethyl)-4-(benzyloxy)phenyl>-2-<(3-benzyloxy)phenyl>ethan-1-ol

: 233597-96-1
1-<2-(2,2-dimethoxyethyl)-4-(benzyloxy)phenyl>-2-<(3-benzyloxy)phenyl>ethanone

Guidance literature:: With oxalyl dichloride; TEA; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 1h;
DOI:10.1021/jo990031g

Reference yield:

: 2973-80-0
2-bromo-5-hydroxybenzaldehyde

: 233597-96-1
1-<2-(2,2-dimethoxyethyl)-4-(benzyloxy)phenyl>-2-<(3-benzyloxy)phenyl>ethanone

Guidance literature:: Multi-step reaction with 5 steps

1: 74 percent / NaH / tetrahydrofuran; dimethylformamide / Ambient temperature

2: 1.) LDA / 1.) THF, room temperature, 1-2 h, 2.) THF, room temperature, 8 h

3: conc. H₂SO₄ / methanol / 4 h / Heating

4: 1.) n-BuLi / 1.) THF, -78 deg C, 1 h, 2.) THF, -78 deg C, 1 h; room temperature, 1 h

5: 94 percent / (COCl)2, DMSO, TEA / CH₂Cl₂ / 1 h / -78 °C

With n-butyllithium; oxalyl dichloride; TEA; sulfuric acid; sodium hydride; dimethyl sulfoxide; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo990031g

Reference yield:

: 85604-06-4
5-(benzyloxy)-2-bromobenzaldehyde

: 233597-96-1
1-<2-(2,2-dimethoxyethyl)-4-(benzyloxy)phenyl>-2-<(3-benzyloxy)phenyl>ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) LDA / 1.) THF, room temperature, 1-2 h, 2.) THF, room temperature, 8 h

2: conc. H₂SO₄ / methanol / 4 h / Heating

3: 1.) n-BuLi / 1.) THF, -78 deg C, 1 h, 2.) THF, -78 deg C, 1 h; room temperature, 1 h

4: 94 percent / (COCl)2, DMSO, TEA / CH₂Cl₂ / 1 h / -78 °C

With n-butyllithium; oxalyl dichloride; TEA; sulfuric acid; dimethyl sulfoxide; lithium diisopropyl amide; In methanol; dichloromethane;
DOI:10.1021/jo990031g