2-BROMO-1-(2-QUINOXALINYL)-1-ETHANONE,97%

Base Information

• Chemical Name: 2-BROMO-1-(2-QUINOXALINYL)-1-ETHANONE,97%
• CAS No.: 35970-57-1
• Molecular Formula: C₁₀H₇BrN₂O
• Molecular Weight: 251.082
• Hs Code.: 2933990090
• Mol file: 35970-57-1.mol

Synonyms:1-(Quinoxalin-2-yl)-2-bromoethanone;2-Bromoacetylquinoxaline

Chemical Property of 2-BROMO-1-(2-QUINOXALINYL)-1-ETHANONE,97%

Chemical Property:

• PSA: 42.85000
• LogP: 2.20740

Purity/Quality:

99%min ^*data from raw suppliers

2-BROMO-1-(2-QUINOXALINYL)-1-ETHANONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R34:Causes burns.
• Hazard Codes: C:Corrosive
• Statements: R34:Causes burns.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36/37/39:Wear suitabl

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BROMO-1-(2-QUINOXALINYL)-1-ETHANONE,97%

There total 5 articles about 2-BROMO-1-(2-QUINOXALINYL)-1-ETHANONE,97% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.2%

2-acetylquinoxaline (25594-62-1) → 1-(quinoxalin-2-yl)-2-bromoethanone (35970-57-1)

Guidance literature:

With pyridinium hydrobromide perbromide; In ethanol; chloroform; at 50 ℃; for 16h;

Reference yield:

2-acetylquinoxaline oxime (78583-89-8) → 1-(quinoxalin-2-yl)-2-bromoethanone (35970-57-1)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. CH₂O

2: 63 percent / Br₂ / dioxane / Heating

With formaldehyd; bromine; In 1,4-dioxane;

Reference yield:

2,3-diethynylquinoxaline (91-19-0) → 1-(quinoxalin-2-yl)-2-bromoethanone (35970-57-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid; silver nitrate; ammonium peroxydisulfate / dichloromethane; water / 2.5 h / 40 °C

2: pyridinium hydrobromide perbromide / chloroform; ethanol / 16 h / 50 °C

With ammonium peroxydisulfate; sulfuric acid; pyridinium hydrobromide perbromide; silver nitrate; In ethanol; dichloromethane; chloroform; water;

upstream raw materials:

2-acetylquinoxaline

2-acetylquinoxaline oxime

2,3-diethynylquinoxaline

Downstream raw materials:

4-methyl-N-(4-(2-(quinoxalin-2-yl)imidazo[1,2-a]pyrazin-8-ylamino)phenyl)benzenesulfonamide

Pd((C₆H₅)2PCH₂CH₂P(C₆H₅)2)(SCHC(C₈H₅N₂)S)

2-(2-Phenyl-thiazol-4-yl)-quinoxaline

Refernces

• 1、 Sarodnick,Kempter. "Hetarylquinoxalines as thiabendazoleanalogs. Part 4: Synthesis of 2-thiazolyl-quinoxalines". . p. 829 - 832. Retrieved 2007/10/02.