(1R,2S)-2-(methyl-{[(1R,2R)-2-phenylcyclopropyl](methyl)}amino)-1-phenylpropan-1-ol

Base Information

Chemical Name:(1R,2S)-2-(methyl-{[(1R,2R)-2-phenylcyclopropyl](methyl)}amino)-1-phenylpropan-1-ol
CAS No.:624732-06-5
Molecular Formula:C₂₀H₂₅NO
Molecular Weight:295.425
Hs Code.:

Synonyms:(1R,2S)-2-(methyl-{[(1R,2R)-2-phenylcyclopropyl](methyl)}amino)-1-phenylpropan-1-ol

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Chemical Property of (1R,2S)-2-(methyl-{[(1R,2R)-2-phenylcyclopropyl](methyl)}amino)-1-phenylpropan-1-ol

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Technology Process of (1R,2S)-2-(methyl-{[(1R,2R)-2-phenylcyclopropyl](methyl)}amino)-1-phenylpropan-1-ol

There total 3 articles about (1R,2S)-2-(methyl-{[(1R,2R)-2-phenylcyclopropyl](methyl)}amino)-1-phenylpropan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 75-11-6
diiodomethane

: 90-86-8
(1R,2S)-2-{methyl-[(E)-3-phenyl-2-propenyl]amino}-1-phenylpropan-1-ol

: 624732-06-5
(1R,2S)-2-(methyl-{[(1R,2R)-2-phenylcyclopropyl](methyl)}amino)-1-phenylpropan-1-ol

Guidance literature:: diiodomethane; With diethylzinc; In hexane; dichloromethane; at 0 ℃; for 0.333333h;

(1R,2S)-2-{methyl-[(E)-3-phenyl-2-propenyl]amino}-1-phenylpropan-1-ol; In hexane; dichloromethane; at 0 ℃; for 48h;
DOI:10.1021/ol035713b

Reference yield:

: 299-42-3,7009-81-6,90-83-5,6912-63-6
ephedrine

: 624732-06-5
(1R,2S)-2-(methyl-{[(1R,2R)-2-phenylcyclopropyl](methyl)}amino)-1-phenylpropan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 96 percent / NaHCO₃ / dimethylformamide / 5 h / 70 °C

2.1: Et₂Zn / hexane; CH₂Cl₂ / 0.33 h / 0 °C

2.2: 95 percent / CH₂Cl₂; hexane / 48 h / 0 °C

With diethylzinc; sodium hydrogencarbonate; In hexane; dichloromethane; N,N-dimethyl-formamide; 2.2: Simmons-Smith cyclopropanation;
DOI:10.1021/ol035713b

Reference yield:

: 4392-24-9
Cinnamyl bromide

: 624732-06-5
(1R,2S)-2-(methyl-{[(1R,2R)-2-phenylcyclopropyl](methyl)}amino)-1-phenylpropan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 96 percent / NaHCO₃ / dimethylformamide / 5 h / 70 °C

2.1: Et₂Zn / hexane; CH₂Cl₂ / 0.33 h / 0 °C

2.2: 95 percent / CH₂Cl₂; hexane / 48 h / 0 °C

With diethylzinc; sodium hydrogencarbonate; In hexane; dichloromethane; N,N-dimethyl-formamide; 2.2: Simmons-Smith cyclopropanation;
DOI:10.1021/ol035713b