Technology Process of 1-(4-benzylmorpholin-2-yl)ethanamine
There total 4 articles about 1-(4-benzylmorpholin-2-yl)ethanamine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-(4-benzylmorpholin-2-yl)ethanone;
With
ammonium acetate; sodium cyanoborohydride;
In
methanol;
at 20 ℃;
for 16h;
Molecular sieve;
Inert atmosphere;
With
sodium hydroxide;
In
water;
pH=12;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: diethyl ether; tetrahydrofuran / 17 h / 0 - 20 °C
1.2: 0 °C
2.1: sodium cyanoborohydride; ammonium acetate / methanol / 16 h / 20 °C / Molecular sieve; Inert atmosphere
2.2: pH 12
With
ammonium acetate; sodium cyanoborohydride;
In
tetrahydrofuran; methanol; diethyl ether;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / dichloromethane / 16 h / 20 °C
2.1: diethyl ether; tetrahydrofuran / 17 h / 0 - 20 °C
2.2: 0 °C
3.1: sodium cyanoborohydride; ammonium acetate / methanol / 16 h / 20 °C / Molecular sieve; Inert atmosphere
3.2: pH 12
With
4-methyl-morpholine; ammonium acetate; sodium cyanoborohydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane;
