1-(1,3-diisopropyldibenzo[b,d]furan-4-yl)-2-phenyl-4,5-dihydro-1H-imidazole

Base Information

• Chemical Name: 1-(1,3-diisopropyldibenzo[b,d]furan-4-yl)-2-phenyl-4,5-dihydro-1H-imidazole
• CAS No.: 1332882-14-0
• Molecular Formula: C₂₇H₂₈N₂O
• Molecular Weight: 396.532
• Mol file: 1332882-14-0.mol

Synonyms:1-(1,3-diisopropyldibenzo[b,d]furan-4-yl)-2-phenyl-4,5-dihydro-1H-imidazole

Chemical Property of 1-(1,3-diisopropyldibenzo[b,d]furan-4-yl)-2-phenyl-4,5-dihydro-1H-imidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(1,3-diisopropyldibenzo[b,d]furan-4-yl)-2-phenyl-4,5-dihydro-1H-imidazole

There total 13 articles about 1-(1,3-diisopropyldibenzo[b,d]furan-4-yl)-2-phenyl-4,5-dihydro-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

N-(1,3-diisopropyldibenzo[b,d]furan-4-yl)acetamide (1332882-12-8) → 1,3-diisopropyldibenzo[b,d]furan-4-amine (1332882-13-9) + 1-(1,3-diisopropyldibenzo[b,d]furan-4-yl)-2-phenyl-4,5-dihydro-1H-imidazole (1332882-14-0)

Guidance literature:

With hydrogenchloride; In methanol; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran;

Reference yield: 54.8%

N-(2-chloro-ethyl)-benzamide (26385-07-9) + 1,3-diisopropyldibenzo[b,d]furan-4-amine (1332882-13-9) → 1-(1,3-diisopropyldibenzo[b,d]furan-4-yl)-2-phenyl-1H-imidazole (1332882-15-1) + 1-(1,3-diisopropyldibenzo[b,d]furan-4-yl)-2-phenyl-4,5-dihydro-1H-imidazole (1332882-14-0)

Guidance literature:

With phosphorus pentachloride; In 5,5-dimethyl-1,3-cyclohexadiene;

Reference yield:

N-(4-dibenzofuranyl)acetamide (50548-37-3) → 1-(1,3-diisopropyldibenzo[b,d]furan-4-yl)-2-phenyl-1H-imidazole (1332882-15-1) + 1-(1,3-diisopropyldibenzo[b,d]furan-4-yl)-2-phenyl-4,5-dihydro-1H-imidazole (1332882-14-0)

Guidance literature:

Multi-step reaction with 6 steps

1: hydrogenchloride / 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; methanol

2: ethyl acetate; N,N-dimethyl-formamide; hexane

3: pyridine / dichloromethane

4: Pt/C; palladium-carbon / ethanol

5: hydrogenchloride / 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; methanol

6: phosphorus pentachloride / 5,5-dimethyl-1,3-cyclohexadiene

With pyridine; hydrogenchloride; phosphorus pentachloride; Pt/C; palladium-carbon; In methanol; 5,5-dimethyl-1,3-cyclohexadiene; ethanol; hexane; dichloromethane; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane

N-(2-chloro-ethyl)-benzamide

1,3-diisopropyldibenzo[b,d]furan-4-amine

N-(4-dibenzofuranyl)acetamide

Downstream raw materials:

1-(1,3-diisopropyldibenzo[b,d]furan-4-yl)-2-phenyl-1H-imidazole