erythro-2-Fluoro-2-phenyl-1-methylethylamine

Base Information

• Chemical Name: erythro-2-Fluoro-2-phenyl-1-methylethylamine
• CAS No.: 75197-98-7
• Molecular Formula: C₉H₁₂FN
• Molecular Weight: 153.199
• Mol file: 75197-98-7.mol

Synonyms:erythro-2-Fluoro-2-phenyl-1-methylethylamine

Chemical Property of erythro-2-Fluoro-2-phenyl-1-methylethylamine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of erythro-2-Fluoro-2-phenyl-1-methylethylamine

There total 7 articles about erythro-2-Fluoro-2-phenyl-1-methylethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(±)-1,1,1,3,3,3-hexafluoroprop-2-yl anti-(1-fluoro-1-phenylpropan-2-yl)carbamate → (1RS,2SR)-1-fluoro-1-phenylpropan-2-amine (75197-98-7)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; water; at 0 ℃; for 1.5h;

DOI:10.1021/jacs.6b07221

Reference yield: 85.0%

(2-Azido-1-fluoro-propyl)-benzene → erythro-2-Fluoro-2-phenyl-1-methylethylamine (75197-98-7)

Guidance literature:

With ammonium formate; palladium on activated charcoal; In methanol; for 24h; Ambient temperature;

DOI:10.1016/S0022-1139(00)82016-3

Reference yield: 83.0%

(1RS,2SR)-1-fluoro-1-phenyl-2-azidopropane → (1RS,2SR)-1-fluoro-1-phenylpropan-2-amine (75197-98-7)

Guidance literature:

(1RS,2SR)-1-fluoro-1-phenyl-2-azidopropane; With triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 0.5h;

With water; In tetrahydrofuran; at 50 ℃; for 2h; optical yield given as %de;

DOI:10.1021/ol100862s

upstream raw materials:

cis-2-Phenyl-3-methylaziridine

trans-2-Phenyl-3-methylaziridine