acetoxymethyl 2-{2-[(4-cyclohexylbenzyl)amino]-6-(cyclopentylamino)-9H-purin-9-yl}acetate

Base Information

Chemical Name:acetoxymethyl 2-{2-[(4-cyclohexylbenzyl)amino]-6-(cyclopentylamino)-9H-purin-9-yl}acetate
CAS No.:1449781-75-2
Molecular Formula:C₂₈H₃₆N₆O₄
Molecular Weight:520.632
Hs Code.:

Synonyms:acetoxymethyl 2-{2-[(4-cyclohexylbenzyl)amino]-6-(cyclopentylamino)-9H-purin-9-yl}acetate

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Chemical Property of acetoxymethyl 2-{2-[(4-cyclohexylbenzyl)amino]-6-(cyclopentylamino)-9H-purin-9-yl}acetate

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Technology Process of acetoxymethyl 2-{2-[(4-cyclohexylbenzyl)amino]-6-(cyclopentylamino)-9H-purin-9-yl}acetate

There total 6 articles about acetoxymethyl 2-{2-[(4-cyclohexylbenzyl)amino]-6-(cyclopentylamino)-9H-purin-9-yl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 590-97-6
acetoxymethyl bromide

: 1255653-14-5
2-(2-((4-cyclohexylbenzyl)amino)-6-(cyclopentylamino)-9H-purin-9-yl)acetic acid

: 1449781-75-2
acetoxymethyl 2-{2-[(4-cyclohexylbenzyl)amino]-6-(cyclopentylamino)-9H-purin-9-yl}acetate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h; Darkness;
DOI:10.1016/j.bmc.2013.04.080

Reference yield:

: 2-(N-tert-butoxycarbonyl)amino-6-chloro-9H-purine

: 1449781-75-2
acetoxymethyl 2-{2-[(4-cyclohexylbenzyl)amino]-6-(cyclopentylamino)-9H-purin-9-yl}acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triphenylphosphine / tetrahydrofuran / 0.03 h / 20 °C / Inert atmosphere

1.2: 0.25 h / 20 °C / Inert atmosphere

2.1: triphenylphosphine / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere

2.2: 20 - 40 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 0.5 h / 135 °C / Sealed tube; Microwave irradiation

4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

5.1: water; lithium hydroxide / tetrahydrofuran / 0.5 h / 20 °C

5.2: pH Ca_. 5.5

6.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C / Darkness

With water; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; 1.1: |Mitsunobu Displacement / 1.2: |Mitsunobu Displacement / 2.1: |Mitsunobu Displacement / 2.2: |Mitsunobu Displacement;
DOI:10.1016/j.bmc.2013.04.080

Reference yield:

: 1236151-75-9
ethyl 2-(2-((tert-butoxycarbonyl)amino)-6-chloro-9H-purin-9-yl)acetate

: 1449781-75-2
acetoxymethyl 2-{2-[(4-cyclohexylbenzyl)amino]-6-(cyclopentylamino)-9H-purin-9-yl}acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere

1.2: 20 - 40 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 0.5 h / 135 °C / Sealed tube; Microwave irradiation

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4.1: water; lithium hydroxide / tetrahydrofuran / 0.5 h / 20 °C

4.2: pH Ca_. 5.5

5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C / Darkness

With water; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; 1.1: |Mitsunobu Displacement / 1.2: |Mitsunobu Displacement;
DOI:10.1016/j.bmc.2013.04.080