3-(4-{1,2-dimethyl-1-[4-(pyridin-2-ylmethoxy)phenyl]propyl}phenyl)-6-(methylsulfonyl)pyridazine

Base Information

Chemical Name:3-(4-{1,2-dimethyl-1-[4-(pyridin-2-ylmethoxy)phenyl]propyl}phenyl)-6-(methylsulfonyl)pyridazine
CAS No.:1094043-54-5
Molecular Formula:C₂₈H₂₉N₃O₃S
Molecular Weight:487.623
Hs Code.:

Synonyms:3-(4-{1,2-dimethyl-1-[4-(pyridin-2-ylmethoxy)phenyl]propyl}phenyl)-6-(methylsulfonyl)pyridazine

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Chemical Property of 3-(4-{1,2-dimethyl-1-[4-(pyridin-2-ylmethoxy)phenyl]propyl}phenyl)-6-(methylsulfonyl)pyridazine

Chemical Property:

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Technology Process of 3-(4-{1,2-dimethyl-1-[4-(pyridin-2-ylmethoxy)phenyl]propyl}phenyl)-6-(methylsulfonyl)pyridazine

There total 3 articles about 3-(4-{1,2-dimethyl-1-[4-(pyridin-2-ylmethoxy)phenyl]propyl}phenyl)-6-(methylsulfonyl)pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1094043-53-4
3-chloro-6-(4-{1,2-dimethyl-1-[4-(pyridin-2-ylmethoxy)phenyl]propyl}phenyl)pyridazine

: 20277-69-4
sodium methansulfinate

: 1094043-54-5
3-(4-{1,2-dimethyl-1-[4-(pyridin-2-ylmethoxy)phenyl]propyl}phenyl)-6-(methylsulfonyl)pyridazine

Guidance literature:: In N,N-dimethyl-formamide; at 120 ℃; for 18h;

Reference yield:

: 2-[(4-{1,2-dimethyl-1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]propyl}phenoxy)methyl]pyridine

: 1094043-54-5
3-(4-{1,2-dimethyl-1-[4-(pyridin-2-ylmethoxy)phenyl]propyl}phenyl)-6-(methylsulfonyl)pyridazine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; water; toluene / 1.5 h / Reflux

2: N,N-dimethyl-formamide / 18 h / 120 °C

With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In ethanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: (-)-2-({4-[1-(4-iodophenyl)-1,2-dimethylpropyl]phenoxy}methyl)pyridine

: 1094043-54-5
3-(4-{1,2-dimethyl-1-[4-(pyridin-2-ylmethoxy)phenyl]propyl}phenyl)-6-(methylsulfonyl)pyridazine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 20 - 80 °C

2: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; water; toluene / 1.5 h / Reflux

3: N,N-dimethyl-formamide / 18 h / 120 °C

With potassium acetate; sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In ethanol; water; N,N-dimethyl-formamide; toluene;