N-{2-[3-(tert-butyl-dimethyl-silanyloxy)-1-(3,4-dichloro-phenyl)-propyl]-[1,3]dithiolan-2-ylmethyl}-3,5-dichloro-N-methyl-benzamide

Base Information

Chemical Name:N-{2-[3-(tert-butyl-dimethyl-silanyloxy)-1-(3,4-dichloro-phenyl)-propyl]-[1,3]dithiolan-2-ylmethyl}-3,5-dichloro-N-methyl-benzamide
CAS No.:484697-83-8
Molecular Formula:C₂₇H₃₅Cl₄NO₂S₂Si
Molecular Weight:639.61
Hs Code.:

<i>N</i>-{2-[3-(<i>tert</i>-butyl-dimethyl-silanyloxy)-1-(3,4-dichloro-phenyl)-propyl]-[1,3]dithiolan-2-ylmethyl}-3,5-dichloro-<i>N</i>-methyl-benzamide

Synonyms:N-{2-[3-(tert-butyl-dimethyl-silanyloxy)-1-(3,4-dichloro-phenyl)-propyl]-[1,3]dithiolan-2-ylmethyl}-3,5-dichloro-N-methyl-benzamide

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Chemical Property of N-{2-[3-(tert-butyl-dimethyl-silanyloxy)-1-(3,4-dichloro-phenyl)-propyl]-[1,3]dithiolan-2-ylmethyl}-3,5-dichloro-N-methyl-benzamide

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Technology Process of N-{2-[3-(tert-butyl-dimethyl-silanyloxy)-1-(3,4-dichloro-phenyl)-propyl]-[1,3]dithiolan-2-ylmethyl}-3,5-dichloro-N-methyl-benzamide

There total 3 articles about N-{2-[3-(tert-butyl-dimethyl-silanyloxy)-1-(3,4-dichloro-phenyl)-propyl]-[1,3]dithiolan-2-ylmethyl}-3,5-dichloro-N-methyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 2905-62-6
3,5-dichlorobenzoyl chloride

: 484697-82-7
{2-[3-(tert-butyl-dimethyl-silanyloxy)-1-(3,4-dichloro-phenyl)-propyl]-[1,3]dithiolan-2-ylmethyl}-methyl-amine

: 484697-83-8
N-{2-[3-(tert-butyl-dimethyl-silanyloxy)-1-(3,4-dichloro-phenyl)-propyl]-[1,3]dithiolan-2-ylmethyl}-3,5-dichloro-N-methyl-benzamide

Guidance literature:: With pyridine; In dichloromethane;
DOI:10.1016/S0960-894X(02)00340-2

Reference yield:

: 184969-89-9
{2-[3-(tert-butyl-dimethyl-silanyloxy)-1-(3,4-dichloro-phenyl)-propyl]-[1,3]dithiolan-2-yl}-methanol

: 484697-83-8
N-{2-[3-(tert-butyl-dimethyl-silanyloxy)-1-(3,4-dichloro-phenyl)-propyl]-[1,3]dithiolan-2-ylmethyl}-3,5-dichloro-N-methyl-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / oxalyl chloride; DMSO; Et₃N / CH₂Cl₂

2: 44 percent / NaCNBH₃ / 2,2,2-trifluoro-ethanol

3: 97 percent / pyridine / CH₂Cl₂

With pyridine; oxalyl dichloride; sodium cyanoborohydride; dimethyl sulfoxide; triethylamine; In dichloromethane; 2,2,2-trifluoroethanol; 1: Swern oxidation;
DOI:10.1016/S0960-894X(02)00340-2

Reference yield:

: 484697-81-6
2-[3-(tert-butyl-dimethyl-silanyloxy)-1-(3,4-dichloro-phenyl)-propyl]-[1,3]dithiolane-2-carbaldehyde

: 484697-83-8
N-{2-[3-(tert-butyl-dimethyl-silanyloxy)-1-(3,4-dichloro-phenyl)-propyl]-[1,3]dithiolan-2-ylmethyl}-3,5-dichloro-N-methyl-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 44 percent / NaCNBH₃ / 2,2,2-trifluoro-ethanol

2: 97 percent / pyridine / CH₂Cl₂

With pyridine; sodium cyanoborohydride; In dichloromethane; 2,2,2-trifluoroethanol;
DOI:10.1016/S0960-894X(02)00340-2