5-chloro-3-hydroxy-1-methyl-3-(phenylethynyl)-1,3-dihydro-2H-indol-2-one

Base Information

• Chemical Name: 5-chloro-3-hydroxy-1-methyl-3-(phenylethynyl)-1,3-dihydro-2H-indol-2-one
• CAS No.: 1621167-78-9
• Molecular Formula: C₁₇H₁₂ClNO₂
• Molecular Weight: 297.741
• Mol file: 1621167-78-9.mol

Synonyms:5-chloro-3-hydroxy-1-methyl-3-(phenylethynyl)-1,3-dihydro-2H-indol-2-one

Chemical Property of 5-chloro-3-hydroxy-1-methyl-3-(phenylethynyl)-1,3-dihydro-2H-indol-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 5-chloro-3-hydroxy-1-methyl-3-(phenylethynyl)-1,3-dihydro-2H-indol-2-one

There total 2 articles about 5-chloro-3-hydroxy-1-methyl-3-(phenylethynyl)-1,3-dihydro-2H-indol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

5-chloro-1-methylindoline-2, 3-dione (60434-13-1) + phenylacetylene (536-74-3) → 5-chloro-3-hydroxy-1-methyl-3-(phenylethynyl)-1,3-dihydro-2H-indol-2-one (1621167-78-9)

Guidance literature:

With copper(l) iodide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In toluene; at 25 ℃; for 0.0833333h; Inert atmosphere;

DOI:10.1055/s-0033-1338563

Reference yield:

phenylethynylmagnesium bromide (6738-06-3) + 5-chloro-1-methylindoline-2, 3-dione (60434-13-1) → 5-chloro-3-hydroxy-1-methyl-3-(phenylethynyl)-1,3-dihydro-2H-indol-2-one (1621167-78-9)

Guidance literature:

In tetrahydrofuran; at 0 ℃; Inert atmosphere;

DOI:10.1002/ejoc.201601030

Reference yield: 96.0%

5-chloro-3-hydroxy-1-methyl-3-(phenylethynyl)-1,3-dihydro-2H-indol-2-one (1621167-78-9) → C17H16ClNO2

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20 ℃; for 2h;

DOI:10.1002/bkcs.11234

upstream raw materials:

5-chloro-1-methylindoline-2, 3-dione

phenylacetylene

phenylethynylmagnesium bromide