(±)-1'-allyl-2-(4-methoxybenzyl)spiro[isoindoline-1,3'-pyrrolidine]-2',3,5'-trione

Base Information

Chemical Name:(±)-1'-allyl-2-(4-methoxybenzyl)spiro[isoindoline-1,3'-pyrrolidine]-2',3,5'-trione
CAS No.:1451076-20-2
Molecular Formula:C₂₂H₂₀N₂O₄
Molecular Weight:376.412
Hs Code.:

Synonyms:(±)-1'-allyl-2-(4-methoxybenzyl)spiro[isoindoline-1,3'-pyrrolidine]-2',3,5'-trione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (±)-1'-allyl-2-(4-methoxybenzyl)spiro[isoindoline-1,3'-pyrrolidine]-2',3,5'-trione

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Technology Process of (±)-1'-allyl-2-(4-methoxybenzyl)spiro[isoindoline-1,3'-pyrrolidine]-2',3,5'-trione

There total 1 articles about (±)-1'-allyl-2-(4-methoxybenzyl)spiro[isoindoline-1,3'-pyrrolidine]-2',3,5'-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1022169-96-5
2-(4-methoxybenzyl)-3-oxo-2,3-dihydro-1H-isoindole-1-carboxylic acid ethyl ester

: 126265-30-3
N-bromoacetyl-2-propenylamine

: 1451076-20-2
(±)-1'-allyl-2-(4-methoxybenzyl)spiro[isoindoline-1,3'-pyrrolidine]-2',3,5'-trione

Guidance literature:: With potassium carbonate; In acetonitrile; for 24h; Inert atmosphere; Reflux;
DOI:10.1016/j.tetlet.2013.07.077

Reference yield:

: 1451076-20-2
(±)-1'-allyl-2-(4-methoxybenzyl)spiro[isoindoline-1,3'-pyrrolidine]-2',3,5'-trione

: N-allyl-2'-hydroxy-2-(4-methoxybenzyl)spiro[isoindoline-1,3'-pyrrolidine]-3,5'-dione

Guidance literature:: With hydrogenchloride; sodium tetrahydroborate; In ethanol; at 0 - 5 ℃;
DOI:10.1016/j.tetlet.2013.07.077

Reference yield:

: 1451076-20-2
(±)-1'-allyl-2-(4-methoxybenzyl)spiro[isoindoline-1,3'-pyrrolidine]-2',3,5'-trione

: N-allyl-2'-hydroxy-2-(4-methoxybenzyl)spiro[isoindoline-1,3'-pyrrolidine]-3,5'-dione

: N-allyl-2'-hydroxy-2-(4-methoxybenzyl)spiro[isoindoline-1,3'-pyrrolidine]-3,5'-dione

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; ethanol; at 0 - 20 ℃; Overall yield = 100 percent;
DOI:10.1039/d0nj04052e