Technology Process of 4-fluoro-2-(3-hydroxy-4-methoxyphenyl)benzothiazole
There total 7 articles about 4-fluoro-2-(3-hydroxy-4-methoxyphenyl)benzothiazole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
methanol;
under 760.051 Torr;
DOI:10.1016/j.bmc.2006.08.026
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 94 percent / K2CO3; KI / dimethylformamide / 22 h / 65 °C
2: 93 percent / sodium chlorite; sulfamic acid; acetic acid / H2O / 1 h / 20 °C
3: 94 percent / thionyl chloride / toluene / 6 h / 100 °C
4: 61 percent / triethylamine / CH2Cl2 / 3 h / Heating
5: 58 percent / Lawesson's reagent; hexamethylphosphoramide / 16 h / 100 °C
6: 26 percent / potassium ferricyanide(III); aq. sodium hydroxide / acetonitrile / 2 h / 90 °C
7: 73 percent / hydrogen / Pd/C / methanol / 760.05 Torr
With
Lawessons reagent; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; sodium chlorite; thionyl chloride; aminosulfonic acid; hydrogen; potassium carbonate; acetic acid; triethylamine; potassium iodide; potassium hexacyanoferrate(III);
palladium on activated charcoal;
In
methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;
6: Jacobson cyclization;
DOI:10.1016/j.bmc.2006.08.026
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 58 percent / Lawesson's reagent; hexamethylphosphoramide / 16 h / 100 °C
2: 26 percent / potassium ferricyanide(III); aq. sodium hydroxide / acetonitrile / 2 h / 90 °C
3: 73 percent / hydrogen / Pd/C / methanol / 760.05 Torr
With
Lawessons reagent; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; hydrogen; potassium hexacyanoferrate(III);
palladium on activated charcoal;
In
methanol; acetonitrile;
2: Jacobson cyclization;
DOI:10.1016/j.bmc.2006.08.026
