methyl 4-(4-(3-tert-butyl-1,2,4-oxadiazol-5-yl)phenylamino)-4-oxobutanoate

Base Information

Chemical Name:methyl 4-(4-(3-tert-butyl-1,2,4-oxadiazol-5-yl)phenylamino)-4-oxobutanoate
CAS No.:1502807-46-6
Molecular Formula:C₁₇H₂₁N₃O₄
Molecular Weight:331.371
Hs Code.:

Synonyms:methyl 4-(4-(3-tert-butyl-1,2,4-oxadiazol-5-yl)phenylamino)-4-oxobutanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 4-(4-(3-tert-butyl-1,2,4-oxadiazol-5-yl)phenylamino)-4-oxobutanoate

Chemical Property:

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Technology Process of methyl 4-(4-(3-tert-butyl-1,2,4-oxadiazol-5-yl)phenylamino)-4-oxobutanoate

There total 8 articles about methyl 4-(4-(3-tert-butyl-1,2,4-oxadiazol-5-yl)phenylamino)-4-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 1502807-44-4
4-(4-(3-tert-butyl-1,2,4-oxadiazol-5-yl)phenylamino)-4-oxobutanoic acid

: 1502807-46-6
methyl 4-(4-(3-tert-butyl-1,2,4-oxadiazol-5-yl)phenylamino)-4-oxobutanoate

Guidance literature:: In diethyl ether; Cooling with ice;
DOI:10.3762/bjoc.9.259

Reference yield:

: 42956-75-2
N'-hydroxypivalimidamide

: 1502807-46-6
methyl 4-(4-(3-tert-butyl-1,2,4-oxadiazol-5-yl)phenylamino)-4-oxobutanoate

Guidance literature:: Multi-step reaction with 3 steps

1: zinc(II) chloride; toluene-4-sulfonic acid / N,N-dimethyl-formamide / 80 °C

2: dichloromethane / 5 h / 20 °C / Inert atmosphere

3: diethyl ether / Cooling with ice

With toluene-4-sulfonic acid; zinc(II) chloride; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.3762/bjoc.9.259

Reference yield:

: 150-13-0,159246-81-8,8014-65-1
4-amino-benzoic acid

: 1502807-46-6
methyl 4-(4-(3-tert-butyl-1,2,4-oxadiazol-5-yl)phenylamino)-4-oxobutanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / Inert atmosphere; Reflux

3.1: dichloromethane / 5 h / 20 °C / Inert atmosphere

4.1: diethyl ether / Cooling with ice

With 1,1'-carbonyldiimidazole; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.3762/bjoc.9.259