N-(4-Benzyl-morpholin-2-ylmethyl)-3,5-dichloro-4-dimethylamino-2-hydroxy-benzamide

Base Information

Chemical Name:N-(4-Benzyl-morpholin-2-ylmethyl)-3,5-dichloro-4-dimethylamino-2-hydroxy-benzamide
CAS No.:126645-58-7
Molecular Formula:C₂₁H₂₅Cl₂N₃O₃
Molecular Weight:438.354
Hs Code.:

Synonyms:N-(4-Benzyl-morpholin-2-ylmethyl)-3,5-dichloro-4-dimethylamino-2-hydroxy-benzamide

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Chemical Property of N-(4-Benzyl-morpholin-2-ylmethyl)-3,5-dichloro-4-dimethylamino-2-hydroxy-benzamide

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Technology Process of N-(4-Benzyl-morpholin-2-ylmethyl)-3,5-dichloro-4-dimethylamino-2-hydroxy-benzamide

There total 8 articles about N-(4-Benzyl-morpholin-2-ylmethyl)-3,5-dichloro-4-dimethylamino-2-hydroxy-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 147767-51-9,126645-52-1
4-benzyl-2-cyanomorpholine

: 126645-58-7
N-(4-Benzyl-morpholin-2-ylmethyl)-3,5-dichloro-4-dimethylamino-2-hydroxy-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) H₂, acetic acid / 1.) Raney nickel / 1.) 95 percent EtOH, RT, 2.) CHCl₃, RT, 2 h

2: 100 percent / 10percent HCl / 4 h / Heating

3: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH₂Cl₂ / 4 h / Ambient temperature

With hydrogenchloride; hydrogen; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; nickel; In dichloromethane;
DOI:10.1021/jm00167a020

Reference yield:

: 104-63-2
N-Benzylethanolamine

: 126645-58-7
N-(4-Benzyl-morpholin-2-ylmethyl)-3,5-dichloro-4-dimethylamino-2-hydroxy-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 3 h / 80 °C

2: concd. H₂SO₄ / 1 h / 150 °C

3: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH₂Cl₂ / 4 h / Ambient temperature

With sulfuric acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1021/jm00167a020

Reference yield:

: 40987-25-5,186293-54-9
N-benzyl-2-chloromethylmorpholine

: 126645-58-7
N-(4-Benzyl-morpholin-2-ylmethyl)-3,5-dichloro-4-dimethylamino-2-hydroxy-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / dimethylformamide / 5 h / Heating

2: 88 percent / 85percent hydrazine monohydrate / ethanol / 0.5 h / Heating

3: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH₂Cl₂ / 4 h / Ambient temperature

With hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00167a020