4-(2-Pyrrolidin-1-ylethoxy)nitrobenzene

Base Information

• Chemical Name: 4-(2-Pyrrolidin-1-ylethoxy)nitrobenzene
• CAS No.: 265654-77-1
• Molecular Formula: C12H16N2O3
• Molecular Weight: 236.271
• Hs Code.: 2933990090
• Mol file: 265654-77-1.mol

Synonyms:1-[2-(4-Nitrophenoxy)ethyl]pyrrolidine;

Chemical Property of 4-(2-Pyrrolidin-1-ylethoxy)nitrobenzene

Chemical Property:

• Vapor Pressure: 5.93E-06mmHg at 25°C
• Refractive Index: 1.562
• Boiling Point: 379.3°Cat760mmHg
• PKA: 9.28±0.20(Predicted)
• Flash Point: 183.2°C
• PSA: 58.29000
• Density: 1.195g/cm³
• LogP: 2.53050
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

1-(2-(4-Nitrophenoxy)ethyl)pyrrolidine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(2-Pyrrolidin-1-ylethoxy)nitrobenzene

There total 12 articles about 4-(2-Pyrrolidin-1-ylethoxy)nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.4%

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + 1-(2-chloroethyl)pyrrolidine hydrochloride (7250-67-1) → 1-(2-(4-nitrophenoxy)ethyl)pyrrolidine (265654-77-1)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 100 ℃; Inert atmosphere;

Reference yield: 70.0%

→ 1-(2-(4-nitrophenoxy)ethyl)pyrrolidine (265654-77-1)

Guidance literature:

Reference yield: 60.0%

1-(2-chloroethyl)pyrrolidine hydrochloride (7250-67-1) + 4-nitrophenol sodium salt (824-78-2) → 1-(2-(4-nitrophenoxy)ethyl)pyrrolidine (265654-77-1)

Guidance literature:

With potassium carbonate; In xylenes; at 130 ℃;

upstream raw materials:

4-(4-nitrophenoxy)butanoic acid

1-(2-chloroethyl)pyrrolidine hydrochloride

4-nitrophenol sodium salt

1-pyrrolidineethanol

Downstream raw materials:

4-(2-pyrrolidinoethoxy)aniline

1-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}guanidine trifluoroacetate salt

Refernces

• 1、 -. "5-HETEROARYL SUBSTITUTED INDAZOLE-3-CARBOXAMIDES AND PREPARATION AND USE THEREOF". Paragraph 0736; 0737. . Retrieved 2019/09/06.
• 2、 Luo, Guoshun,Chen, Mingqi,Lyu, Weiting,Zhao, Ruheng,Xu, Qian,You, Qidong,Xiang, Hua. "Design, synthesis, biological evaluation and molecular docking studies of novel 3-aryl-4-anilino-2H-chromen-2-one derivatives targeting ERα as anti-breast cancer agents". . p. 2668 - 2673. Retrieved 2017/05/29.