1-phenyl-2-[(S)-1-aminoethyl]-N,N-diethylcyclopropanecarboxamide

Base Information

• Chemical Name: 1-phenyl-2-[(S)-1-aminoethyl]-N,N-diethylcyclopropanecarboxamide
• CAS No.: 171889-06-8
• Molecular Formula: C₁₆H₂₄N₂O
• Molecular Weight: 260.379
• Mol file: 171889-06-8.mol

Synonyms:1-phenyl-2-[(S)-1-aminoethyl]-N,N-diethylcyclopropanecarboxamide

Chemical Property of 1-phenyl-2-[(S)-1-aminoethyl]-N,N-diethylcyclopropanecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-phenyl-2-[(S)-1-aminoethyl]-N,N-diethylcyclopropanecarboxamide

There total 10 articles about 1-phenyl-2-[(S)-1-aminoethyl]-N,N-diethylcyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(1S,2R)-1-Phenyl-2-[(S)-1-(N-benzyl-N-hydroxyamino)ethyl]-N,N-diethylcyclopropanecarboxamide (288627-97-4) → 1-phenyl-2-[(S)-1-aminoethyl]-N,N-diethylcyclopropanecarboxamide (171889-06-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1016/S0040-4039(00)00823-6

Reference yield: 97.0%

(1S,2R)-1-phenyl-2-<(S)-1-azidoethyl>-N,N-diethylcyclopropanecarboxamide (171889-15-9) → 1-phenyl-2-[(S)-1-aminoethyl]-N,N-diethylcyclopropanecarboxamide (171889-06-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1016/0040-4039(95)02221-X

Reference yield:

(1S,2R)-2-Formyl-1-phenyl-cyclopropanecarboxylic acid diethylamide (172016-00-1) → 1-phenyl-2-[(S)-1-aminoethyl]-N,N-diethylcyclopropanecarboxamide (171889-06-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 93 percent / molecular sieves 4 Angstroem / CH₂Cl₂ / 1 h / 20 °C

2.1: MgBr₂ / diethyl ether; tetrahydrofuran / 0.5 h / 20 °C

2.2: 80 percent / diethyl ether; tetrahydrofuran / 8 h / -78 °C

3.1: H₂ / 10percent Pd/C / methanol / 72 h / 1551.49 Torr

With 4 A molecular sieve; hydrogen; magnesium bromide; 10percent Pd/C; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;

DOI:10.1039/b008230i

upstream raw materials:

(1S,2R)-1-phenyl-2-<(S)-1-azidoethyl>-N,N-diethylcyclopropanecarboxamide

(1S,2R)-1-Phenyl-2-[(S)-1-(N-benzyl-N-hydroxyamino)ethyl]-N,N-diethylcyclopropanecarboxamide

(1S,2R)-2-Formyl-1-phenyl-cyclopropanecarboxylic acid diethylamide

N-[(1R,2S)-2-(N,N-Diethylcarbamoyl)-2-phenylcyclopropylmethylene]benzylamine N-oxide