2,7,12-tris-[2-[4-formyl-2-propargyloxyphenoxy]ethoxy]-3,8,13-trimethoxy-10,15-dihydro-2H-tribenzo[a,d,g]cyclononene

Base Information

• Chemical Name: 2,7,12-tris-[2-[4-formyl-2-propargyloxyphenoxy]ethoxy]-3,8,13-trimethoxy-10,15-dihydro-2H-tribenzo[a,d,g]cyclononene
• CAS No.: 1224386-65-5
• Molecular Formula: C₆₀H₅₄O₁₅
• Molecular Weight: 1015.08
• Mol file: 1224386-65-5.mol

Synonyms:2,7,12-tris-[2-[4-formyl-2-propargyloxyphenoxy]ethoxy]-3,8,13-trimethoxy-10,15-dihydro-2H-tribenzo[a,d,g]cyclononene

Chemical Property of 2,7,12-tris-[2-[4-formyl-2-propargyloxyphenoxy]ethoxy]-3,8,13-trimethoxy-10,15-dihydro-2H-tribenzo[a,d,g]cyclononene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,7,12-tris-[2-[4-formyl-2-propargyloxyphenoxy]ethoxy]-3,8,13-trimethoxy-10,15-dihydro-2H-tribenzo[a,d,g]cyclononene

There total 1 articles about 2,7,12-tris-[2-[4-formyl-2-propargyloxyphenoxy]ethoxy]-3,8,13-trimethoxy-10,15-dihydro-2H-tribenzo[a,d,g]cyclononene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

4-hydroxy-3-(prop-2-yn-1-yloxy)benzaldehyde + (±)-2,7,12-trimethoxy-3,8,13-tris(2-bromoethoxy)-10,15-dihydro-5H-tribenzo[a,d,g]cyclononene (188120-06-1) → 2,7,12-tris-[2-[4-formyl-2-propargyloxyphenoxy]ethoxy]-3,8,13-trimethoxy-10,15-dihydro-2H-tribenzo[a,d,g]cyclononene (1224386-65-5)

Guidance literature:

With caesium carbonate; In dimethyl sulfoxide; at 55 ℃; Inert atmosphere;

DOI:10.1021/ol200088f

Reference yield: 90.0%

2,7,12-tris-[2-[4-formyl-2-propargyloxyphenoxy]ethoxy]-3,8,13-trimethoxy-10,15-dihydro-2H-tribenzo[a,d,g]cyclononene (1224386-65-5) → 2,7,12-tris-[2-[4-(hydroxymethyl)-2-propargyloxyphenoxy]ethoxy]-3,8,13-trimethoxy-10,15-dihydro-2H-tribenzo[a,d,g]cyclononane

Guidance literature:

With sodium tetrahydroborate; In methanol; chloroform; Inert atmosphere;

DOI:10.1021/jacs.5b01938

Reference yield:

2,7,12-tris-[2-[4-formyl-2-propargyloxyphenoxy]ethoxy]-3,8,13-trimethoxy-10,15-dihydro-2H-tribenzo[a,d,g]cyclononene (1224386-65-5) → 6,6',6''-((((3,8,13-trimethoxy-10,15-dihydro-5H-tribenzo[a,d,g][9]annulene-2,7,12-triyl)tris-(oxy))tris(ethane-2,1-diyl))tris(oxy))tris(3-(hydroxymethyl)phenol) (1268721-37-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / tetrahydrofuran; methanol / 4.33 h / -10 - 20 °C

2: dichlorobis(tri-O-tolylphosphine)palladium; water; triethylamine / tetrahydrofuran / 80 °C / Inert atmosphere

With sodium tetrahydroborate; dichlorobis(tri-O-tolylphosphine)palladium; water; triethylamine; In tetrahydrofuran; methanol;

DOI:10.1021/ol200088f

upstream raw materials:

(±)-2,7,12-trimethoxy-3,8,13-tris(2-bromoethoxy)-10,15-dihydro-5H-tribenzo[a,d,g]cyclononene

Downstream raw materials:

6,6',6''-((((3,8,13-trimethoxy-10,15-dihydro-5H-tribenzo[a,d,g][9]annulene-2,7,12-triyl)tris-(oxy))tris(ethane-2,1-diyl))tris(oxy))tris(3-(hydroxymethyl)phenol)