N-(3-(5-(oxazol-5-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrrol-1-yl)phenyl)-propane-2-sulfonamide

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Chemical Name:N-(3-(5-(oxazol-5-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrrol-1-yl)phenyl)-propane-2-sulfonamide
CAS No.:1430724-37-0
Molecular Formula:C₂₃H₂₁N₅O₃S
Molecular Weight:447.517
Hs Code.:

Synonyms:N-(3-(5-(oxazol-5-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrrol-1-yl)phenyl)-propane-2-sulfonamide

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Chemical Property of N-(3-(5-(oxazol-5-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrrol-1-yl)phenyl)-propane-2-sulfonamide

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Technology Process of N-(3-(5-(oxazol-5-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrrol-1-yl)phenyl)-propane-2-sulfonamide

There total 12 articles about N-(3-(5-(oxazol-5-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrrol-1-yl)phenyl)-propane-2-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 10147-37-2
Isopropylsulfonyl chloride

: 1430728-04-3
3-(5-(oxazol-5-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrrol-1-yl)aniline

: 1430724-37-0
N-(3-(5-(oxazol-5-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrrol-1-yl)phenyl)-propane-2-sulfonamide

Guidance literature:: With pyridine; In dichloromethane; for 1h;

Reference yield:

: 42564-51-2
4-fluoro-3-nitrobenzaldehyde

: 1430724-37-0
N-(3-(5-(oxazol-5-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrrol-1-yl)phenyl)-propane-2-sulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium fluoride / N,N-dimethyl-formamide / 4 h / 130 °C

2.1: potassium carbonate / methanol / 0.17 h / 20 °C

2.2: 4 h / Reflux

3.1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 12 h / Inert atmosphere

4.1: 0.5 h / 100 °C

5.1: sodium hydroxide; water / ethanol / 5 h / 85 °C

6.1: pyridine / dichloromethane / 1 h

With pyridine; potassium fluoride; palladium 10% on activated carbon; water; hydrogen; potassium carbonate; sodium hydroxide; In methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 1430724-37-0
N-(3-(5-(oxazol-5-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrrol-1-yl)phenyl)-propane-2-sulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid; nitric acid / 1.33 h / 0 - 20 °C

2.1: potassium fluoride / N,N-dimethyl-formamide / 4 h / 130 °C

3.1: potassium carbonate / methanol / 0.17 h / 20 °C

3.2: 4 h / Reflux

4.1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 12 h / Inert atmosphere

5.1: 0.5 h / 100 °C

6.1: sodium hydroxide; water / ethanol / 5 h / 85 °C

7.1: pyridine / dichloromethane / 1 h

With pyridine; potassium fluoride; sulfuric acid; palladium 10% on activated carbon; water; hydrogen; nitric acid; potassium carbonate; sodium hydroxide; In methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;